Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients.
Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients.
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Slit2 和 Robo1 的低表达与乳腺癌患者的不良预后和脑特异性转移相关。
DOI：
10.1038/srep14430
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发表时间：
2015-09-24
影响因子：
4.6
通讯作者：
Ma Y
中科院分区：
文献类型：
--
作者：
Qin F;Zhang H;Ma L;Liu X;Dai K;Li W;Gu F;Fu L;Ma Y
脑转移是乳腺癌治疗中一个重要的临床难题。其预后差，发病率高。近年来，研究发现Slit 2/Robo 1通路参与了乳腺癌的发生发展。然而，到目前为止，还没有令人信服的报告表明Slit 2/Robo 1轴是否在乳腺癌脑转移中有任何作用。在这项研究中，我们首次研究了Slit 2/Robo 1信号与乳腺癌脑转移的相关性。我们的研究结果表明：（1）Slit 2和Robo 1低表达的浸润性导管癌患者预后差，脑转移特异性强，而肝、骨和肺转移则无明显差异。(2)Slit 2和Robo 1在脑转移患者中的表达低于无脑转移患者，尤其是在脑转移瘤中。(3)Slit 2和Robo 1低表达组患者从乳腺癌诊断到脑转移以及脑转移到死亡的时间均明显短于高表达组。总体而言，我们的研究结果表明，Slit 2/Robo 1轴可能被视为预测乳腺癌患者脑转移的重要临床参数。
Brain metastasis is a significant unmet clinical problem in breast cancer treatment. It is always associated with poor prognosis and high morbidity. Recently, Slit2/Robo1 pathway has been demonstrated to be involved in the progression of breast carcinoma. However, until present, there are no convincing reports that suggest whether the Slit2/Robo1 axis has any role in brain metastasis of breast cancer. In this study, we investigated the correlation between Slit2/Robo1 signaling and breast cancer brain metastasis for the first time. Our results demonstrated that (1) Invasive ductal carcinoma patients with low expression of Slit2 or Robo1 exhibited worse prognosis and brain-specific metastasis, but not liver, bone or lung. (2) Lower expression of Slit2 and Robo1 were observed in patients with brain metastasis, especially in their brain metastasis tumors, compared with patients without brain metastasis. (3) The interval from diagnosis of breast cancer to brain metastasis and brain metastasis to death were both much shorter in patients with low expression of Slit2 or Robo1 compared with the high expression group. Overall, our findings indicated that Slit2/Robo1 axis possibly be regarded as a significant clinical parameter for predicting brain metastasis in breast cancer patients.