An Acute Ocfentanil Fatality: A Case Report with Postmortem Concentrations
An Acute Ocfentanil Fatality: A Case Report with Postmortem Concentrations
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DOI：
10.1093/jat/bkw096
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发表时间：
2016-11-16
影响因子：
2.5
通讯作者：
Briellmann, T. A.
中科院分区：
文献类型：
--
作者：
Dussy, F. E.;Hangartner, S.;Briellmann, T. A.
一名24岁的男子被发现死在他的公寓里。在尸体附近发现了一个装有数百毫克棕色粉末的可重新关闭的塑料拉链袋，调查人员的第一个假设是死于海洛因中毒。因此，下令进行法律的尸检。以下毒理学分析显示尿液和棕色粉末中含有奥芬太尼。本文介绍了四种测定外周全血中奥芬太尼浓度的方法。实现了奥芬太尼的富集。根据该参考，可以确定所缉获粉末中的奥芬太尼浓度为0.91%。还使用标准添加程序测定了采样体液中的奥芬太尼浓度。在外周血中测得9.1 μ g/L，在心脏血中测得27.9 μ g/L，在尿中测得480 μ g/L。此外，抗抑郁药西酞普兰、神经安定药奎替卡松和大麻素在尿液中发现，随后在外周血中定量。
A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first assumption of the investigators was death due to heroin intoxication. Therefore, a legal autopsy was ordered. The following toxicological analysis revealed ocfentanil in urine and in the brown powder. Four different approaches for the determination of the ocfentanil concentrations in peripheral whole blood are described. Enrichment of ocfentanil from the powder was realized. With this reference, it was possible to determine the ocfentanil concentration in the seized powder to be 0.91%. Concentrations of ocfentanil were also determined in the sampled body fluids using the standard addition procedure. In peripheral blood 9.1 mu g/L, in heart blood 27.9 mu g/L and in urine 480 mu g/L were measured. In addition, the antidepressant citalopram, the neuroleptic quetiapine and cannabinoids were found in urine and subsequently quantified in peripheral blood.