Fibrogenesis in kidney transplantation: potential targets for prevention and therapy.
Fibrogenesis in kidney transplantation: potential targets for prevention and therapy.
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DOI：
10.1097/tp.0b013e3181bcccea
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发表时间：
2009-11-27
期刊：
影响因子：
6.2
通讯作者：
Samaniego M
中科院分区：
文献类型：
--
作者：
Djamali A;Samaniego M
同种异体肾纤维化是由体液和细胞事件介导的反应过程以及转化生长因子β-1 (TGF-β1) 的激活引起的。这是一个涉及实质细胞和移植物浸润细胞的过程，如果损伤持续存在或对损伤的反应过度，可能会导致器官衰竭。在这篇综述中，我们将讨论针对肾同种异体移植纤维发生的预防和治疗策略的作用。我们的结论是，除了预防策略外，基于 BMP-7、HGF、CTGF 和吡非尼酮的疗法在临床前研究中也显示出了有希望的结果。需要进行临床试验来检验这些疗法对长期结果的影响。
Kidney allograft fibrosis results from a reactive process mediated by humoral and cellular events and the activation of transforming growth factor beta-one (TGF-β1). It is a process that involves both parenchymal and graft infiltrating cells and can lead to organ failure if injury persists or if the response to injury is excessive. In this review we will address the role of preventive and therapeutic strategies that target kidney allograft fibrogenesis. We conclude that in addition to preventive strategies, therapies based on BMP-7, HGF, CTGF and pirfenidone have shown promising results in preclinical studies. Clinical trials are needed to examine the effect of these therapies on long-term outcomes.