Serum Copeptin Predicts Severity and Recurrent Stroke in Ischemic Stroke Patients
Serum Copeptin Predicts Severity and Recurrent Stroke in Ischemic Stroke Patients
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血清和肽素可预测缺血性中风患者的严重程度和复发性中风
DOI：
10.1007/s12640-017-9754-5
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发表时间：
2017-10-01
影响因子：
3.7
通讯作者：
Ji, Xiang
中科院分区：
文献类型：
--
作者：
Tang, Wan-Zhong;Wang, Xiao-Bo;Ji, Xiang
几项研究调查了和肽素在中风中的预后作用。本研究的目的是评估血清中的和肽素水平，并在缺血性中风患者的一年随访研究中调查其与复发中风风险的关系。在这项事后分析中，我们在入院时测量了 316 名缺血性中风患者的血清和肽素水平和 NIHS 中风量表 (NIHSS)。终点是一年随访后卒中复发。我们使用逻辑回归模型来评估和肽素水平与复发性中风风险之间的关系。考虑传统危险因素的逻辑回归分析显示，当血清和肽素用作连续变量时，血清和肽素水平与中至高临床严重程度之间存在关系（OR，1.05；95% CI，1.03-1.09）。随访中，54名患者（17.1%）出现中风复发。和肽素四分位数的中风复发事件分布范围为 5.1%（第一个四分位数）至 23.1%（第四个四分位数）。在多变量模型中，将和肽素的第三个四分位数（OR = 2.78；95% CI 1.85–3.53）和第四个四分位数（OR = 4.00；95% CI 2.86–6.50）与第一个四分位数进行比较，发现和肽素水平与中风复发事件相关。较高的血清和肽素水平是中风患者入院时严重程度和一年后中风复发的预测因子。
Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of 316 patients with ischemic stroke. The end point was stroke recurrence after 1-year follow-up. We used logistic regression model to assess the relationship between copeptin levels and risk recurrent stroke. Logistic regression analysis considering traditional risk factors showed a relationship between serum copeptin levels and moderate-to-high clinical severity when serum copeptin was used as a continuous variable (OR, 1.05; 95% CI, 1.03–1.09). In the follow-up, 54 patients (17.1%) had a stroke recurrence. The stroke recurrence events distribution across the copeptin quartiles ranged between 5.1% (first quartile) to 23.1% (fourth quartile). In multivariate models comparing the third (OR = 2.78; 95% CI 1.85–3.53) and fourth quartiles (OR = 4.00; 95% CI 2.86–6.50) against the first quartile of the copeptin, levels of copeptin were associated with stroke recurrence events. A higher serum copeptin level is a predictor of both severity at admission and stroke recurrence at 1-year in stroke patients.