HPV-associated lung cancers: an international pooled analysis
HPV-associated lung cancers: an international pooled analysis
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DOI：
10.1093/carcin/bgu038
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发表时间：
2014-06-01
期刊：
影响因子：
4.7
通讯作者：
Taioli, Emanuela
中科院分区：
文献类型：
--
作者：
Ragin, Camille;Obikoya-Malomo, Monisola;Taioli, Emanuela
人乳头瘤病毒（HPV）是宫颈癌的致病危险因素。一些研究表明与肺肿瘤的一个子集的关联，但病因学联系尚未确定。我们对横断面研究（27个数据集，n = 3249例患者）进行了国际汇总分析，以评估肺癌中HPV DNA的患病率，并根据临床和人口统计学特征调查病毒的存在。HPV 16/18是最常检测到的，但不同地理区域之间的病毒流行率存在很大差异。HPV 16/18的最高患病率在南美洲和中美洲观察到，其次是亚洲，北美和欧洲（调整后的患病率分别为22%，5%，4%和3%）。除北美外，每个地理区域的HPV 16患病率均高于HPV 18。在白色人种中观察到HPV 16/18阳性肺癌的可能性较低（校正比值比[OR] = 0.33，95%置信区间[CI] = 0.12-0.90），而未观察到与性别、吸烟史、年龄、组织学或分期相关。肺癌组织中HPV阳性率高于正常肺组织（OR = 3.86，95% CI = 2.87-5.19）。在HPV 16阳性肿瘤患者的一个子集中，整合主要发生在女性患者中（93%，13/14），而男性病例（N = 14）的身体状况不一致。我们的研究结果证实，HPV DNA存在于一小部分肺肿瘤中，具有较大的地理差异。需要进一步的综合分析来评估这种关联是否反映了因果关系。
Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of cross-sectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.