Mobile assessment of heightened skin conductance in posttraumatic stress disorder
Mobile assessment of heightened skin conductance in posttraumatic stress disorder
复制标题
DOI：
10.1002/da.22610
复制
发表时间：
2017-06-01
影响因子：
7.4
通讯作者：
Jovanovic, Tanja
中科院分区：
文献类型：
--
作者：
Hinrichs, Rebecca;Michopoulos, Vasiliki;Jovanovic, Tanja
背景心理生理反应性增加是创伤后应激障碍（PTSD）的一个标志性中间表型。与没有 PTSD 的创伤幸存者相比，患有 PTSD 的个体对创伤脚本表现出更大的皮肤电导 (SC) 反应。然而，创伤脚本需要时间来开发，并且不能在单次访问中轻松使用。因此，需要一种低成本、易于使用的 SC 记录协议来进行 PTSD 评估。方法使用连接到便携式平板电脑的移动设备 (eSense)，我们评估了从佐治亚州亚特兰大格雷迪纪念医院招募的 63 名参与者在创伤暴露后大约 1 年的 SC 反应性。 SC 反应 (SCR) 是通过从 STI 期间的最大 SCL 中减去基线记录结束时的 SC 水平 (SCL) 来计算的。结果与基线相比，STI 期间的 SCL 显着较高 (P < .001)，并且患有 PTSD 的个体比没有 PTSD 的个体表现出显着更高的 SCR (P = .006)。使用 SCR 和 PTSD 诊断作为结果的逻辑回归显示比值比为 1.76 (95% CI: 1.11-2.78)。最后，STI 期间较高的 SCR 也与控制人口统计学和创伤严重程度的 PTSD 症状总分显着相关（b = 0.42，P = .001）。结论当前的研究证明了使用移动设备评估 PTSD 患者心理生理反应性的可行性。使用这种低成本、易于使用的移动设备来收集与性传播感染相关的客观生理数据，可以在临床和研究环境中轻松传播。
BackgroundIncreased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be easily used in a single visit. Thus, there is a need for a low-cost, easy-to-use, SC recording protocol for PTSD assessment.MethodsUsing a mobile device (eSense) connected to a portable tablet computer, we assessed SC reactivity to a standard trauma interview (STI) in 63 participants recruited from Grady Memorial Hospital in Atlanta, GA, approximately 1 year after trauma exposure. SC response (SCR) was calculated by subtracting the SC level (SCL) at the end of the baseline recording from the maximum SCL during the STI.ResultsSCL was significantly higher during the STI compared to baseline (P < .001), and individuals with PTSD showed significantly greater SCR than individuals without PTSD (P = .006). Logistic regression using SCR with PTSD diagnosis as the outcome showed an odds ratio of 1.76 (95% CI: 1.11-2.78). Lastly, higher SCR during the STI was also significantly associated with PTSD symptom total score controlling for demographics and trauma severity (b = 0.42, P = .001).ConclusionsThe current study demonstrated feasibility of the use of a mobile device for assessing psychophysiological reactivity in those with PTSD. The use of this low-cost, easy-to-use mobile device to collect objective physiological data in concert with a STI can be easily disseminated in clinical and research settings.