A new front in cell invasion: The invadopodial membrane.
A new front in cell invasion: The invadopodial membrane.
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细胞入侵的新锋：侵袭性膜。
DOI：
10.1016/j.ejcb.2016.06.006
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发表时间：
2016-11
影响因子：
6.6
通讯作者：
Sherwood, David R.
中科院分区：
文献类型：
--
作者：
Hastie, Eric L.;Sherwood, David R.
关键词：
侵袭伪足是富含F-肌动蛋白的膜突起，其在细胞侵袭期间突破基底膜屏障。自30多年前发现以来，侵袭伪足在体外癌细胞中得到了广泛的研究，在了解其组成、形成、细胞骨架调节和基质金属蛋白酶MT 1-MMP运输控制方面取得了巨大进展。相反，很少有研究invadopodia已在体内进行，离开他们的生理调节不清楚。最近的活细胞成像和基因扰动研究在C。秀丽线虫已经揭示，侵袭伪足形成有独特的侵袭伪足膜，由其专门的脂质和相关的蛋白质组成限定，其通过内溶酶体快速再循环。在这里，我们提供了侵袭足膜保守的证据，并讨论了其在穿越基底膜屏障方面可能的功能。侵袭伪足膜的发现和检查对于理解侵袭伪足在正常和疾病环境中的调节、组装和功能具有重要意义。
Invadopodia are F-actin-rich membrane protrusions that breach basement membrane barriers during cell invasion. Since their discovery more than 30 years ago, invadopodia have been extensively studied in cancer cells in vitro, where great advances in understanding their composition, formation, cytoskeletal regulation, and control of the matrix metalloproteinase MT1-MMP trafficking have been made. In contrast, few studies examining invadopodia have been conducted in vivo, leaving their physiological regulation unclear. Recent live-cell imaging and gene perturbation studies in C. elegans have revealed that invadopodia are formed with a unique invadopodial membrane, defined by its specialized lipid and associated protein composition, which is rapidly recycled through the endolysosome. Here, we provide evidence that the invadopodial membrane is conserved and discuss its possible functions in traversing basement membrane barriers. Discovery and examination of the invadopodial membrane has important implications in understanding the regulation, assembly, and function of invadopodia in both normal and disease settings.
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影响因子：
4
作者：
Gawden-Bone, Christian;Zhou, Zhongjun;Lucocq, John
通讯作者：
Lucocq, John
影响因子：
3.4
作者：
Dinic, Jelena;Ashrafzadeh, Parham;Parmryd, Ingela
通讯作者：
Parmryd, Ingela
影响因子：
6.6
作者：
Artym, Vira V.;Matsumoto, Kazue;Yamada, Kenneth M.
通讯作者：
Yamada, Kenneth M.
影响因子：
--
作者：
CHEN, WT
通讯作者：
CHEN, WT
DOI：
10.1083/jcb.201312098
发表时间：
2014-03-31
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hagedorn EJ;Kelley LC;Naegeli KM;Wang Z;Chi Q;Sherwood DR
通讯作者：
Sherwood DR