Vitamin A intake and the risk of hip fracture in postmenopausal women: the Iowa Women's Health Study
Vitamin A intake and the risk of hip fracture in postmenopausal women: the Iowa Women's Health Study
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DOI：
10.1007/s00198-003-1577-y
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发表时间：
2004-07-01
影响因子：
4
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Lim, LS;Harnack, LJ;Folsom, AR
过量摄入维生素A被认为会通过诱发骨质疏松症对骨骼产生有害影响。这可能导致骨折的风险增加，特别是在已经有骨质疏松症风险的人中。然而，很少有研究专门研究通过饮食和补充剂的使用摄入维生素A与社区老年妇女骨折的关系。我们对来自爱荷华州妇女健康研究的34,703名绝经后妇女进行了前瞻性随访，以确定通过食物和补充剂摄入高水平的维生素A和视黄醇是否与髋部骨折或所有骨折的风险增加相关。半定量食物频率问卷被用来获得参与者的基线维生素A和视黄醇摄入量。参与者被随访了平均9.5年的事件自我报告的髋关节和非髋关节骨折。经过多变量校正后，结果显示，与不使用补充剂的人相比，使用含维生素A补充剂的人（n=525）发生髋部骨折的风险增加了1.18倍（95%CI，0.99至1.41），但没有证据表明补充剂使用者（n= 6，502）发生所有骨折的风险增加。也没有证据表明髋骨骨折风险与补充剂中维生素A或视黄醇含量的增加存在剂量反应关系。此外，我们的研究结果表明，从食物和补充剂中或仅从食物中摄入维生素A或视黄醇与髋部或所有骨折的风险之间没有关联。总之，我们发现在一组年龄较大的绝经后妇女中，维生素A或视黄醇的摄入量越高，髋部骨折或所有骨折的风险越高。
Excessive intake of vitamin A is postulated to have a detrimental effect on bone by inducing osteoporosis. This may lead to an increased risk of fracture, particularly in persons who are already at risk of osteoporosis. However, few studies have specifically examined the association of vitamin A intake through diet and supplement use, with fractures in a cohort of older, community-dwelling women. We prospectively followed a cohort of 34,703 postmenopausal women from the Iowa Women's Health Study to determine if high levels of vitamin A and retinol intake through food and supplement use were associated with an increased risk of hip or all fractures. A semiquantitative food frequency questionnaire was used to obtain the participants' baseline vitamin A and retinol intake. Participants were followed for a mean duration of 9.5 years for incident self-reported hip and nonhip fractures. After multivariate adjustment, it was revealed that users of supplements containing vitamin A had a 1.18-fold increased risk of incident hip fracture (n=525) compared with nonusers (95% CI, 0.99 to 1.41), but there was no evidence of an increased risk of all fractures (n=6,502) among supplement users. There was also no evidence of a dose-response relationship in hip fracture risk with increasing amounts of vitamin A or retinol from supplements. Furthermore, our results showed no association between vitamin A or retinol intake from food and supplements, or food only, and the risk of hip or all fractures. In conclusion, we found little evidence of an increased risk of hip or all fractures with higher intakes of vitamin A or retinol among a cohort of older, postmenopausal women.