MicroRNAs in immune response and macrophage polarization.
MicroRNAs in immune response and macrophage polarization.
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DOI：
10.1161/atvbaha.112.300068
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发表时间：
2013-02
期刊：
影响因子：
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通讯作者：
Abraham E
中科院分区：
文献类型：
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作者：
Liu G;Abraham E
炎症对于对抗入侵的微生物病原体至关重要。在这个过程中，多个免疫细胞群体的参与对于建立最佳免疫应答至关重要。在过去的十年中，一类新的非编码小RNA，称为miRNA，已经成为生物过程中的重要调节因子。miRNA在炎症和免疫应答中的重要作用通过研究而突出，其中证明miRNA的失调伴随与过度或不受控制的炎症相关的疾病。在这篇简短的综述中，我们总结了miRNAs在先天性和适应性免疫反应中的作用。我们讨论了miRNA在巨噬细胞极化中的作用，巨噬细胞极化是一种对炎症有明显影响的分子事件。
Inflammation is essential to combat invading microbial pathogens. In this process, the involvement of multiple immune cell populations is critical in mounting an optimum immune response. In the past decade, a new class of non-coding small RNAs, called miRNAs, has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive or uncontrolled inflammation. In this brief review, we summarize the roles of miRNAs that have been characterized in innate and adaptive immune responses. We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear impact on inflammation.