MULTIPLE FACTORS IN THIRST
MULTIPLE FACTORS IN THIRST
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DOI：
10.1152/ajplegacy.1954.178.3.538
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发表时间：
1954-01-01
影响因子：
--
通讯作者：
HOY, PA
中科院分区：
文献类型：
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作者：
ADOLPH, EF;BARKER, JP;HOY, PA
通过控制技术对大鼠和兔子的口渴进行的研究表明，两种刺激中的任何一种都是诱导饮水所必需的：体内水分的耗尽或体内浓度过高的溶质。对血浆高渗。通过三种途径加入不同剂量的NaCl（或尿素）。饮酒是在它们被吸收到血液循环中之后进行的。不同的氯离子吸收率从三个网站的admn。这在很大程度上解释了饮酒的差异。水喝得足够多。将盐稀释至约0.4/meq./ L.，并将其排泄到浓缩液中，但从来没有足够的amts。以使盐与对照体液等渗。通过严格的约束、灌胃、通过其他途径饮水，可以部分抑制饮酒。大剂量的匹妥辛，可卡因的口腔，或放置高浓度。在饮用水中的溶质。唯一的方法是在饮用水中加入稀释的溶质（特别是氯化钠）。生理适应被确定在wt。在剥夺水的损失，并在饮用NaCl admn。
The study of thirst in rats and rabbits by a controlled technique showed that either of two kinds of stimuli was necessary to induce drinking: depletion of body water or excess in the body of a solute in a concn. hypertonic to blood plasma. Diverse doses of NaCl (or urea) were added by three routes. Drinking followed upon their absorption into the circulation. Diverse rates of chloride absorption from the three sites of admn. largely accounted for the differences of drinking. Water was drunk in sufficient amts. to dilute the salt to about 0.4/meq./l., and to excrete it in that concn., but never in sufficient amts. to render the salt isotonic with control body fluids. Drinking could be partially inhibited by severe restraint, filling of the stomach, of water by other routes, injn. of large doses of Pitressin, cocainization of the mouth, or placing high concns. of solutes in the drinking water. The only method found of enhancing drinking in rats was to place dilute solutes (especially NaCl) in drinking water. Physiological adaptations were identified in wt. losses during deprivation of water, and in drinking after NaCl admn.