Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma.
Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma.
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DOI：
10.1016/j.dadm.2017.01.007
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Jensen MK
中科院分区：
文献类型：
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作者：
Koch M;Furtado JD;Falk K;Leypoldt F;Mukamal KJ;Jensen MK
载脂蛋白的亚种可以通过基于共存载脂蛋白的存在和不存在来分级分离载脂蛋白来定义。在22名无痴呆的受试者中，我们确定了酶联免疫吸附测定法测量的血浆和脑脊液（CSF）载脂蛋白（apoA-I、apoC-III、apoE和apoJ）或载脂蛋白亚类（apoA-I伴或不伴apoC-III、apoE或apoJ; apoE伴或不伴apoC-III或apoJ）的年龄和性别校正相关性。CSF载脂蛋白E与血浆载脂蛋白或其亚种无关。CSF apoJ与血浆apoA-I无apoJ相关性最强（r = 0.7）。CSF apoA-I与血浆总apoA-I和所有apoA-I亚种（r ≥ 0.4）相似，但apoA-I与apoE（r = 0.3）或apoA-I与apoJ（r = 0.3）除外。CSF apoC-III与血浆apoA-I和apoC-III的相关性最强（r = 0.7）。与痴呆的病理生理学有关的某些载脂蛋白的CSF水平可能比总血浆浓度更接近特定的血浆载脂蛋白亚种。
Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins. We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay–measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants. CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (r = 0.7). CSF apoA-I correlated similarly strong with plasma total apoA-I and all apoA-I subspecies (r ≥ 0.4) except for apoA-I with apoE (r = 0.3) or apoA-I with apoJ (r = 0.3). CSF apoC-III was most strongly correlated with plasma apoA-I with apoC-III (r = 0.7). CSF levels of some apolipoproteins implicated in the pathophysiology of dementia might be better approximated by specific plasma apolipoprotein subspecies than total plasma concentrations.