Galectins in parasite infection and allergic inflammation
Galectins in parasite infection and allergic inflammation
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DOI：
10.1023/b:glyc.0000014091.00844.0a
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Meeusen, EN
中科院分区：
文献类型：
--
作者：
Young, AR;Meeusen, EN
Galectins被越来越多地认为是体内平衡和疾病调节的重要免疫调节因子。本文对半乳糖凝集素参与寄生虫感染和变态反应性炎症这两种截然不同但在免疫上有联系的现象的研究现状进行了综述。Galectins由寄生虫和宿主产生，似乎与寄生虫的建立密切相关，并指导感染过程和免疫反应。宿主Galectins也被证明是细胞向炎症部位募集的积极参与者，并调节肥大细胞、中性粒细胞和嗜酸性粒细胞的效应功能。此外，Galectins诱导白细胞细胞因子基因差异表达的能力表明，它们能够引导适应性免疫反应的性质，特别是T2型过敏反应。
Galectins are increasingly recognised as important immunological mediators of homeostasis and disease regulation. This paper gives an overview of current knowledge of galectin involvement in parasite infection and allergic inflammation, two very different but immunologically linked phenomena. Galectins are produced by both the parasite and the host and appear to be intimately involved in parasite establishment, as well as directing the course of infection and the immune response. Host galectins have also been shown to be active participants in the recruitment of cells to sites of inflammation and modulating the effector function of mast cells, neutrophils and eosinophils. Moreover, the ability of galectins to induce differential expression of cytokine genes in leukocytes suggests that they are able to direct the nature of an adaptive immune response, in particular towards a T2-type allergic response.