Gap detection measured with electrically evoked auditory event-related potentials and speech-perception abilities in children with auditory neuropathy spectrum disorder.
Gap detection measured with electrically evoked auditory event-related potentials and speech-perception abilities in children with auditory neuropathy spectrum disorder.
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DOI：
10.1097/aud.0b013e3182944bb5
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发表时间：
2013-11
期刊：
影响因子：
3.7
通讯作者：
Buchman CA
中科院分区：
文献类型：
--
作者：
He S;Grose JH;Teagle HF;Woodard J;Park LR;Hatch DR;Buchman CA
本研究旨在探讨电诱发听觉事件相关电位（eERP）对听神经病谱系障碍（ANSD）儿童的可行性，包括起始P1-N1-P2波和电诱发听觉变化波（EACC）对时间间隔的反应，并评价这些指标与ANSD儿童言语感知能力的关系。15名ANSD儿童（他们是Cochiar Nucleus器械用户）参与了本研究。对于每个受试者，绕过语音处理器麦克风，并通过直接刺激一个中间阵列电极（电极12）来诱发eERP。刺激是一系列持续时间为800 ms的双相电流脉冲。两种基本刺激条件用于诱发eERP。在无间隙条件下，整个脉冲串不间断地传递到电极12，并且相对于刺激起始测量起始P1-N1-P2复合体。在间隙条件下，刺激由两个脉冲串组成，每个脉冲串的持续时间为400 ms，依次出现在同一电极上，并由五个间隙（即5，10，20，50和100 ms）之一隔开。这些科目与ANSD的开放集言语知觉能力进行了评估，使用语音平衡幼儿园（PBK）的单词列表在60分贝SPL使用监听现场语音在一个健全的展台。记录所有参与本研究的ANSD受试者的eERPs。言语知觉表现良好（对PBK单词的正确率> 70%）和较差的受试者之间，P1-N1-P2复合波起始的重测信度、均方根（RMS）振幅或P1潜伏期无显著差异。一般来说，EACC表现出不太成熟的形态学特征比发病P1-N1-P2反应记录从同一个主题。有一个强大的PBK字分数和EACC阈值之间的相关性间隙检测。在这项研究中，言语感知能力较差的受试者表现出较大的EACC阈值。这些结果证明了使用直接电刺激记录植入ANSD儿童的eERPs的可行性。时间处理缺陷，表现为大的EACC阈值的差距检测，可能部分原因是在植入ANSD受试者的亚组中观察到的言语感知性能差。这一发现表明，EACC引起的时间连续性（即差距）的变化持有承诺作为植入ANSD儿童的言语感知能力的预测。
This study aimed 1) to investigate the feasibility of recording the electrically evoked auditory event-related potential (eERP), including the onset P1-N1-P2 complex and the electrically evoked auditory change complex (EACC) in response to temporal gaps, in children with auditory neuropathy spectrum disorder (ANSD); and 2) to evaluate the relationship between these measures and speech perception abilities in these subjects. Fifteen ANSD children who are Cochlear Nucleus device users participated in this study. For each subject, the speech processor microphone was bypassed and the eERPs were elicited by direct stimulation of one mid-array electrode (electrode 12). The stimulus was a train of biphasic current pulses 800 ms in duration. Two basic stimulation conditions were used to elicit the eERP. In the no-gap condition, the entire pulse train was delivered uninterrupted to electrode 12, and the onset P1-N1-P2 complex was measured relative to the stimulus onset. In the gapped condition, the stimulus consisted of two pulse train bursts, each being 400 ms in duration, presented sequentially on the same electrode and separated by one of five gaps (i.e. 5, 10, 20, 50, and 100 ms). Open-set speech perception ability of these subjects with ANSD was assessed using the Phonetically Balanced Kindergarten (PBK) word lists presented at 60 dB SPL using monitored live voice in a sound booth. The eERPs were recorded from all subjects with ANSD who participated in this study. There were no significant differences in test-retest reliability, root mean squared (RMS) amplitude or P1 latency for the onset P1-N1-P2 complex between subjects with good (> 70% correct on PBK words) and poorer speech-perception performance. In general, the EACC showed less mature morphological characteristics than the onset P1-N1-P2 response recorded from the same subject. There was a robust correlation between the PBK word scores and the EACC thresholds for gap detection. Subjects with poorer speech-perception performance showed larger EACC thresholds in this study. These results demonstrate the feasibility of recording eERPs from implanted children with ANSD using direct electrical stimulation. Temporal processing deficits, as demonstrated by large EACC thresholds for gap detection, might account in part for the poor speech-perception performances observed in a subgroup of implanted subjects with ANSD. This finding suggests that the EACC elicited by changes in temporal continuity (i.e. gap) holds promise as a predictor of speech perception ability among implanted children with ANSD.