PLATELET-DERIVED GROWTH-FACTOR PROMOTES DIVISION AND MOTILITY AND INHIBITS PREMATURE DIFFERENTIATION OF THE OLIGODENDROCYTE TYPE-2 ASTROCYTE PROGENITOR-CELL
PLATELET-DERIVED GROWTH-FACTOR PROMOTES DIVISION AND MOTILITY AND INHIBITS PREMATURE DIFFERENTIATION OF THE OLIGODENDROCYTE TYPE-2 ASTROCYTE PROGENITOR-CELL
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DOI：
10.1038/333560a0
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发表时间：
1988-06-09
期刊：
影响因子：
64.8
通讯作者：
RIDDLE, P
中科院分区：
文献类型：
--
作者：
NOBLE, M;MURRAY, K;RIDDLE, P
在中枢神经系统发育过程中调节细胞间相互作用的有丝分裂原尚不清楚。为数不多的相互作用之一，充分理解，允许识别这样的分子涉及两个胶质细胞谱系，使大鼠视神经。该组织中的一个胶质细胞群体，即1型星形胶质细胞1，分泌一种可溶性因子，促进第二个双能少突胶质细胞/2型星形胶质细胞（O-2A）祖细胞群体的分裂2;这些祖细胞产生少突胶质细胞，其在CNS中形成大轴突，以及2型星形胶质细胞，其包裹Ranvier节点处的裸露轴突3，4。1型星形胶质细胞还促进祖细胞运动性5，并抑制祖细胞向少突胶质细胞的过早分化，当这些细胞在1型星形胶质细胞不存在的情况下生长时发生这种情况2，3。我们现在已经发现，血小板衍生生长因子模拟1型星形胶质细胞对O-2A祖细胞的作用，并且PDGF抗体阻断1型星形胶质细胞的作用。
The mitogens which modulate cell–cell interactions during development of the central nervous system are unknown. One of the few interactions sufficiently well understood to allow identification of such molecules involves the two glial lineages which make up the rat optic nerve. One population of glial cells in this tissue, the type-1 astrocytes1, secrete a soluble factor(s) which promotes division of a second population of bipotential oligoden-drocyte/type-2 astrocyte (O-2A) progenitor cells2; these progenitors give rise to oligodendrocytes, which myelinate large axons in the CNS, and type-2 astrocytes, which enwrap bare axons at nodes of Ranvier3,4. Type-1 astrocytes also promote progenitor motility5, and inhibit the premature differentiation of progenitors into oligodendrocytes which occur when these cells are grown in the absence of type-1 astrocytes2,3. We have now found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects of type-1 astrocytes.