Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats
Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats
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DOI：
10.1016/s0893-133x(97)00130-9
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发表时间：
1998-02-01
影响因子：
7.6
通讯作者：
Koob, GF
中科院分区：
文献类型：
--
作者：
Heyser, CJ;Schulteis, G;Koob, GF
阿坎酸（乙酰基高牛磺酸钙）是一种相对较新的化合物，开发用于治疗酒精中毒，并已被证明可有效减少人类酗酒者的复发。在当前的研究中，在有限的使用范式中使用口服乙醇自我给药的动物模型进一步检查了该药物的作用。雄性 Wistar 大鼠经过训练，在两杆自由选择操作条件下对乙醇（10% w/v）或水做出反应。急性给药阿坎酸（400 mg/kg）减少了乙醇消耗并增加了对水的反应。长期服用较低每日剂量的阿坎酸（100 和 200 mg/kg）可阻止大鼠在强制戒酒期后通常观察到的乙醇消耗增加。阿坎酸的这种作用对乙醇具有选择性，因为在任何测试剂量下，对水的反应均不受影响。大鼠的这些结果提出了一个探索阿坎酸抗复发作用机制的模型。 (C) 1998 年美国神经精神药理学学院。由爱思唯尔科学公司出版
Acamprosate (calcium-acetyl homotaurinate) is a relatively new compound developed for the treatment of alcoholism and has been shown to be effective in attenuating relapse in human alcoholics. In the current study, the effects of this drug were further examined using an animal model of oral ethanol self-administration in a limited access paradigm. Male Wistar rats were trained to respond for ethanol (10% w/v) or water in a two-lever free-choice operant condition. Acute administration acamprosate (400 mg/kg) reduced ethanol consumption and increased responding for water. Chronic administration of lower daily doses of acamprosate (100 and 200 mg/kg) blocked the increased ethanol consumption typically observed in rats after an imposed abstinence period. This effect of acamprosate was selective for ethanol, as responding for water was unaffected at any dose tested. These results with rats suggest a model by which to explore the mechanisms for anti-relapse effects of acamprosate. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.