Sustained attention in mice: Expanding the translational utility of the SAT by incorporating the Michigan Controlled Access Response Port (MICARP)
Sustained attention in mice: Expanding the translational utility of the SAT by incorporating the Michigan Controlled Access Response Port (MICARP)
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DOI：
10.1016/j.bbr.2011.08.025
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发表时间：
2011-12-01
影响因子：
2.7
通讯作者：
Sarter, Martin
中科院分区：
文献类型：
--
作者：
Peters, Megan St.;Cherian, Ajeesh Koshy;Sarter, Martin
小鼠基因技术的进步激发了人们对小鼠认知任务发展的越来越大的兴趣。在这里，我们描述和讨论了必要的修改，以适应用于评估小鼠持续注意表现的任务，包括对这种表现的自上而下的控制征税。持续注意任务(SAT)的有效性，包括分心物版本(DSAT)，以前已经在大鼠和人类身上得到了证明。这项任务需要可移动或可伸缩的操作台：将操作台插入操作室，提示动物对先前的信号或非信号事件做出反应，分别报告命中或未命中，或正确拒绝或错误警报。可伸缩的杠杆不能支持足够高和稳定的小鼠表现水平。鉴于静态拨鼻器广泛用于测试小鼠的操作能力，因此，我们设计并制造了一种可伸缩的拨鼻器。当这个装置延伸到腔室中时，一个用来戳鼻子的洞慢慢地打开，然后随着装置的收缩再次关闭(被称为“密歇根受控访问响应端口”，MICARP)。结果描述了信号持续时间和事件发生率的变化、试验结果和试验类型概率的变化、小鼠剥夺程度的影响以及SAT和DSAT表现的可靠性。小鼠进行SAT和DSAT的水平与大鼠观察到的水平相当。这项任务将有助于扩大SAT和DSAT的翻译效用。(C)2011爱思唯尔B.V.保留所有权利。
Advances in mouse genetic technology have spurred increasing interest in the development of cognitive tasks for mice. Here, we describe and discuss the modifications necessary to adapt a task for the assessment of sustained attention performance for use in mice, including for taxing the top-down control of such performance. The validity of the Sustained Attention Task (SAT), including the distractor version (dSAT), has previously been demonstrated in rats and humans. This task requires moveable or retractable operanda: insertion of operanda into the operant chambers cues animals to respond to a prior signal or non-signal event, reporting either a hit or a miss, or a correct rejection or false alarm, respectively. Retractable levers did not support sufficiently high and stable levels of performance in mice. Given the widespread use of static nose-poke devices for testing operant performance in mice, we therefore designed and fabricated a retractable nose-poke device. As this device extends into chambers, a hole for nose-poking is slowly opened and closed again as the device retracts (termed the "Michigan Controlled Access Response Port", MICARP). Results describe the effects of variation of signal duration and event rate, trial outcome and trial type probability, effects of mice deprivation levels, and the reliability of SAT and dSAT performance. Mice perform the SAT and dSAT at levels comparable to those observed in rats. This task will be of assistance in expanding the translational usefulness of the SAT and dSAT. (C) 2011 Elsevier B.V. All rights reserved.