Long intergenic noncoding RNAs: new links in cancer progression.
Long intergenic noncoding RNAs: new links in cancer progression.
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DOI：
10.1158/0008-5472.can-10-2483
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发表时间：
2011-01-01
期刊：
影响因子：
11.2
通讯作者：
Chang HY
中科院分区：
文献类型：
--
作者：
Tsai MC;Spitale RC;Chang HY
癌症转移的过程由一系列连续而复杂的步骤组成。在这里，我们给出了一个观点，在癌症进展的非编码转录的最新结果，专注于长的基因间非编码RNA（lincRNA）的新兴作用。LincRNA靶向染色质修饰复合物或RNA结合蛋白以改变基因表达程序。与miRNA类似，lincRNA在原发性肿瘤和转移瘤中表现出不同的基因表达模式。我们讨论了lincRNA如何用于癌症诊断，预后，并作为潜在的治疗靶点。
The process of cancer metastasis consists of a series of sequential and complex steps. Here we give a perspective on recent results of non-coding transcription in cancer progression, focusing on the emerging role of long intergenic non-coding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA binding proteins to alter gene expressing programs. Similar to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be utilized for cancer diagnosis, prognosis, and serve as potential therapeutic targets.