Measurement delay associated with the Guardian® RT continuous glucose monitoring system
Measurement delay associated with the Guardian® RT continuous glucose monitoring system
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DOI：
10.1111/j.1464-5491.2009.02887.x
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发表时间：
2010-01-01
影响因子：
3.5
通讯作者：
Hovorka, R.
中科院分区：
文献类型：
--
作者：
Wei, C.;Lunn, D. J.;Hovorka, R.
目的 使用房室模型，我们评估了 1 型糖尿病 (T1D) 年轻受试者的血糖与由 Guardian (R) RT 连续血糖监测系统测量的传感器葡萄糖之间的时间延迟。方法 12 名接受连续皮下胰岛素输注治疗的 T1D 儿童和青少年（男/女 7/5；年龄 13.1 +/- 4.2 岁；体重指数 21.9 +/- 4.3 kg/m(2)；平均值 +/- sd）在临床研究机构中进行了超过 19 小时的研究。 Guardian (R) RT 每 6 小时校准一次，传感器葡萄糖每 5 分钟测量一次。使用 YSI 2300 STAT Plus 分析仪每 15 分钟测量一次参考血糖。采用传感器葡萄糖-血糖动力学的群体区室模型来估计时间延迟、校准量程和校准偏移。结果时间延迟的群体中位数为15.8（四分位距15.2，16.5）分钟，血糖与延迟15分钟的传感器葡萄糖之间的相关性分析证实了这一点。延迟的个体间差异相对较低，95% 的人预计延迟时间在 10.4 至 24.3 分钟之间。量表和位移的人群中位数（四分位距）分别为 0.800 (0.777, 0.823)（无单位）和 1.66 (1.47, 1.84) mmol/l。 结论 在患有 T1D 的年轻受试者中，与 Guardian (R) RT 系统相关的总时间延迟约为 15 分钟。这是基于生理原因的预期的两倍，表明由于数据处理而导致 5 到 10 分钟的延迟。很少观察到超过 25 分钟的延误。
Aims Using compartment modelling, we assessed the time delay between blood glucose and sensor glucose measured by the Guardian (R) RT continuous glucose monitoring system in young subjects with Type 1 diabetes (T1D).Methods Twelve children and adolescents with T1D treated by continuous subcutaneous insulin infusion (male/female 7/5; age 13.1 +/- 4.2 years; body mass index 21.9 +/- 4.3 kg/m(2); mean +/- sd) were studied over 19 h in a Clinical Research Facility. Guardian (R) RT was calibrated every 6 h and sensor glucose measured every 5 min. Reference blood glucose was measured every 15 min using a YSI 2300 STAT Plus Analyser. A population compartment model of sensor glucose-blood glucose kinetics was adopted to estimate the time delay, the calibration scale and the calibration shift.Results The population median of the time delay was 15.8 (interquartile range 15.2, 16.5) min, which was corroborated by correlation analysis between blood glucose and 15-min delayed sensor glucose. The delay has a relatively low intersubject variability, with 95% of individuals predicted to have delays between 10.4 and 24.3 min. Population medians (interquartile range) for the scale and shift are 0.800 (0.777, 0.823) (unitless) and 1.66 (1.47, 1.84) mmol/l, respectively.Conclusions In young subjects with T1D, the total time delay associated with the Guardian (R) RT system was approximately 15 min. This is twice that expected on physiological grounds, suggesting a 5-to 10-min delay because of data processing. Delays above 25 min are rarely to be observed.