Acute toxicity in the guinea pig and in vitro "dioxin-like" activity of the environmental contaminant 1,2,4,5,7,8-hexachloro (9H)xanthene.
Acute toxicity in the guinea pig and in vitro "dioxin-like" activity of the environmental contaminant 1,2,4,5,7,8-hexachloro (9H)xanthene.
复制标题
环境污染物 1,2,4,5,7,8-六氯 (9H)xanthene 对豚鼠的急性毒性和体外“二恶英样”活性。
DOI：
10.1080/15287398709530978
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kleopfer,RD
中科院分区：
文献类型：
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作者：
DeCaprio,AP;Briggs,R;Gierthy,JF;Kim,JC;Kleopfer,RD
密苏里州的一些场所由于不适当的废油粉尘控制而受到多氯二苯并二恶英和二苯并呋喃的污染。除这些化合物外，还检测到相对较高水平的1，2，4，5，7，8-六氯（9 H）氧杂蒽（1，2，4，5，7，8-HCX），这是六氯环己烷生产的副产品。与二苯并二恶英和二苯并呋喃不同，没有关于氯化氧杂蒽的动物毒性数据。鉴于这类新型环境污染物的潜在重要性，进行了研究，以检查豚鼠的急性口服毒性和1，2，4，5，7，8-HCX的体外“二恶英样”活性。单次经口给予0.02、0.1、0.5或2.5 mg 1，2，4，5，7，8-HCX/kg玉米油溶液并在42天后处死的动物未出现给药相关病理学。给予12.5 mg/kg的豚鼠显示轻度至中度膨胀和组织学上可观察到的膀胱浆膜下水肿，以及胰腺腺泡细胞轻度脂肪空泡化。认为这些变化的毒理学意义极小。在任何剂量水平下均未观察到化合物或剂量相关死亡、体重减轻或器官重量变化。使用“二恶英样”活性的体外生物测定法的结果证实了初步数据，表明在该测定系统中，1，2，4，5，7，8-HCX的效力比2，3，7，8-四氯二苯并对二恶英（2，3，7，8-TCDD）低约106倍。这些发现表明，与2，3，7，8-TCDD相比，1，2，4，5，7，8-HCX可能代表相对较低的环境危害。
A number of sites in the state of Missouri have been contaminated with polychlorinated dibenzodioxins and dibenzofurans as a result of improper waste‐oil application for dust control. In addition to these compounds, relatively high levels of 1,2,4,5,7,8‐hexachloro(9H)xanthene (1,2,4,5,7,8‐HCX), a by‐product of hexachlorophene manufacture, were also detected. Unlike the dibenzodioxins and dibenzofurans, no animal toxicity data are available on the chlorinated xanthenes. In view of the potential importance of this novel class of environmental contaminants, studies were conducted to examine the acute oral toxicity in guinea pigs and in vitro “dioxin‐like” activity of 1,2,4,5,7,8‐HCX. Animals administered a single oral dose of 0.02, 0.1, 0.5 or 2.5 mg 1,2,4,5,7,8‐HCX/kg in corn oil and sacrificed 42 d later exhibited no treatment‐related pathology. Guinea pigs given 12.5 mg/kg displayed mild to moderate distension and histologically observable subserosal edema of the urinary bladder, in addition to mild fatty vacuolization of pancreatic acinar cells. These alterations were considered to be of minimal toxicological significance. No compound‐ or dose‐related mortality, body weight loss, or organ weight changes were noted at any dose level. Results using an in vitro bioassay for “dioxin‐like” activity confirmed preliminary data suggesting that 1,2,4,5,7,8‐HCX is about 106times less potent than 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (2,3,7,8‐TCDD) in this assay system. These findings indicate that 1,2,4,5,7,8‐HCX may represent a relatively low environmental hazard compared to 2,3,7,8‐TCDD.