Contribution of norepinephrine to emotional memory consolidation during sleep
Contribution of norepinephrine to emotional memory consolidation during sleep
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DOI：
10.1016/j.psyneuen.2011.03.006
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发表时间：
2011-10-01
影响因子：
3.7
通讯作者：
Born, Jan
中科院分区：
文献类型：
--
作者：
Groch, Sabine;Wilhelm, Ines;Born, Jan
背景：越来越多的证据表明，慢波睡眠（SWS）支持记忆巩固。这种效应可能部分源于在存在张力性降低的NE水平的情况下SWS期间发生的阶段性去甲肾上腺素能（NE）活性。在这里，我们研究了NE是否支持巩固杏仁核依赖的情感记忆在SWS.Methods：在一项双盲交叉研究中，15名男性学习的情感和中性材料（故事，图片）在晚上前3小时的早期SWS丰富的保留睡眠，在此期间，无论是安慰剂或可乐定，α 2-肾上腺素能受体激动剂，阻断蓝斑NE释放，静脉输注。记忆检索以及情感评级和心率反应的图片learning.Results后23小时进行了评估：可乐定降低血浆NE水平，但对SWS没有影响。虽然保留的故事内容的话和图片本身不受影响，可乐定明显地阻止了优势的情绪相比，中性记忆的时间顺序，与这种优势的情绪相比，中性记忆只观察到在安慰剂条件。对图片的心率反应没有受到影响，但在安慰剂条件下，熟悉的负面图片被评为不那么令人兴奋，与以前没有见过的图片相比，具有更多的负面效价;这些差异在可乐定后被消除。考虑到对事件时间顺序的记忆比对项目的记忆更依赖于海马体，我们的研究结果表明，在早期SWS丰富的睡眠中NE活动促进记忆的巩固，这涉及到强的杏仁核和海马成分。(C)2011爱思唯尔有限公司保留所有权利。
Background: There is increasing evidence indicating that slow wave sleep (SWS) supports memory consolidation. This effect may in part originate from phasic noradrinergic (NE) activity occurring during SWS in the presence of tonically lowered NE levels. Here, we examined whether NE supports the consolidation of amygdala-dependent emotional memory during SWS.Methods: In a double-blind cross-over study, 15 men learned emotional and neutral materials (stories, pictures) in the evening before a 3-h period of early SWS-rich retention sleep, during which either placebo or clonidine, an alpha 2-adrenoceptor agonist which blocks locus coeruleus NE release, was intravenously infused. Memory retrieval as well as affective ratings and heart rate responses to the pictures were assessed 23 h after learning.Results: Clonidine reduced plasma NE levels but had no effect on SWS. While retention of story content words and pictures per se remained unaffected, clonidine distinctly blocked the superiority of emotional compared to neutral memory for temporal order, with this superiority of emotional over neutral memories observed only in the placebo condition. Heart rate responses to pictures were not affected, but whereas under placebo conditions familiar negative pictures were rated less arousing and with a more negative valence compared to pictures not seen before; these differences were abolished after clonidine.Conclusion: Given that memory for the temporal order of events depends on the hippocampus to a greater extent than item memory, our findings suggest that NE activity during early SWS-rich sleep facilitates consolidation of memories that involve both, a strong amygdalar and hippocampal component. (C) 2011 Elsevier Ltd. All rights reserved.