Epidemiology of major depression with atypical features: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
Epidemiology of major depression with atypical features: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
复制标题
具有非典型特征的严重抑郁症的流行病学：来自国家酒精和相关疾病的国家流行病学调查的结果（NESARC）。
DOI：
10.4088/jcp.10m06227
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Hasin DS
中科院分区：
文献类型：
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作者：
Blanco C;Vesga-López O;Stewart JW;Liu SM;Grant BF;Hasin DS
研究具有和不具有非典型特征的终生重度抑郁发作(MDE)患者的患病率、相关性、共病和寻求治疗情况。数据来自2001-2002年全国酒精及相关疾病流行病学调查，这是对美国人口中具有代表性的样本(N=43,093)的大型横断面调查，使用酒精使用障碍和相关残疾面试表-DSM-IV版(AUDADIS-IV)评估精神障碍。根据符合终生DSM-IV MDE标准的个体是否有嗜睡或吞噬过多来定义对照组。与没有非典型特征的MDE相比，在MDE期间出现非典型特征与终生精神共病的发生率更高，包括酗酒、药物依赖、恶劣心境、社交焦虑症、特殊恐惧症和除反社会人格障碍(PD)外的任何人格障碍(PD)。与后者相比，具有不典型特征的MDE与女性、发病年龄较小、MDES较多、发作严重程度和残疾程度较高、抑郁症家族史、双相I型障碍、自杀未遂和较大的心理健康就诊率有关。我们的数据为这一抑郁指标的临床意义和有效性提供了进一步证据。根据在MDE期间出现的两种逆转的植物症状中的任何一种，我们的研究证实了大多数经常被引用的非典型抑郁症的确认者。具有非典型特征的MDE可能比以前报道的更常见、更严重、更严重。
To examine prevalence, correlates, comorbidity and treatment-seeking among individuals with a lifetime major depressive episode (MDE) with and without atypical features. Data were derived from the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions, a large cross-sectional survey of a representative sample (N = 43,093) of the U.S. population, which assessed psychiatric disorders using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). Comparison groups were defined based on the presence or absence of hypersomnia or hyperphagia in individuals who meet criteria for lifetime DSM-IV MDE. The presence of atypical features during a MDE was associated with greater rates of lifetime psychiatric comorbidity, including alcohol abuse, drug dependence, dysthymia, social anxiety disorder, specific phobia and any personality disorder (PD), except antisocial PD, than MDE without atypical features. Compared with the later group, MDE with atypical features was associated with female gender, younger age of onset, more MDEs, greater episode severity and disability, higher rates of family history of depression, bipolar I disorder, suicide attempts, and larger mental health treatment-seeking rates. Our data provide further evidence for the clinical significance and validity of this depressive specifier. Based on the presence of any of the two reversed vegetative symptoms during an MDE most of the commonly cited validators of atypical depression were confirmed in our study. MDE with atypical features may be more common, severe, and impairing than previously documented.