Functional correction of episomal mutations withshort DNA fragments and RNA–DNA oligonucleotides
Functional correction of episomal mutations withshort DNA fragments and RNA–DNA oligonucleotides
复制标题
使用短 DNA 片段和 RNA-DNA 寡核苷酸对附加型突变进行功能校正
作者：
P. H. Thorpe;B. Stevenson;D. Porteous
基因校正是替代基因治疗的另一种方法。通过纠正基因组内的突变，避免了有效基因治疗的一些障碍。同源核酸序列可以通过诱导重组或错配修复来校正突变。近年来，利用短DNA片段（SDF）和RNA-DNA寡核苷酸（RDO）实现临床基因校正的实验策略得到了令人鼓舞的数据。
Gene correction is an alternative approach to replacement gene therapy. By correcting mutations within the genome, some of the barriers to effective gene therapy are avoided. Homologous nucleic acid sequences can correct mutations by inducing recombination or mismatch repair. Recently, encouraging data have been presented using both short DNAfragments (SDFs) and RNA–DNA oligonucleotides (RDOs) in experimental strategies to realize clinical gene correction.
上皮细胞中 RNA-DNA 寡核苷酸的基因靶向事件的不同频率。
DOI：
10.1046/j.1523-1747.1998.00403.x
发表时间：
1998
期刊：
The Journal of investigative dermatology.
影响因子：
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作者：
Santana,E;Peritz,AE;Iyer,S;Uitto,J;Yoon,K
通讯作者：
Yoon,K