Immunoscintigraphy of adenocarcinomas by means of radiolabeled F(ab')2 fragments of an anti-carcinoembryonic antigen monoclonal antibody: a multicenter study.
Immunoscintigraphy of adenocarcinomas by means of radiolabeled F(ab')2 fragments of an anti-carcinoembryonic antigen monoclonal antibody: a multicenter study.
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使用抗癌胚抗原单克隆抗体的放射性标记 F(ab)2 片段对腺癌进行免疫闪烁扫描：一项多中心研究。
作者：
A. Siccardi;G. Buraggi;L. Callegaro;A. C. Colella;P. D. De Filippi;G. Galli;G. Mariani;R. Masi;R. Palumbo;P. Riva
抗癌胚抗原（CEA）单克隆抗体F023 C5的F（ab '）2片段被确定为比完整IgG和Fab片段更适合用于免疫闪烁显像，用131 I标记或与DTPA缀合用于即时111 In标记，并静脉内施用。（2-3 mCi/0.5mg）对11个核医学科的509例患者进行了治疗，其中胃肠道腺癌284例，非胃肠道腺癌204例，对照组21例;血清CEA升高169例，正常115例，未测定225例。获得以下结果：（a）无不良反应;（B）324例患者的肿瘤显像（特别是在81.5%CEA血清阳性和69.0%CEA血清阴性患者中）;（c）11个科室的结果之间的灵敏度无显著差异;（d）131 I和111 In标记的免疫放射性药物之间的总体灵敏度无显著差异;（e）CEA血清阳性患者中记录的病变成像分数为73.3%，CEA血清阴性患者中为53.7%;（f）肝转移的检测受到非特异性放射性摄取的阻碍，特别是当使用111 In标记试剂时;（g）免疫闪烁成像阴性结果的主要原因是肿瘤病变中缺乏CEA，如免疫组织化学所记录的;（h）病变大小也很重要，因为直径达2厘米的病变的灵敏度为64%，较大病变的灵敏度为84%;（i）记录到许多“意外”的放射定位。大多数被确定为隐匿性肿瘤病变。在35例患者中，这一发现有助于早期发现肿瘤复发。
F(ab')2 fragments of anti-carcinoembryonic antigen (CEA) monoclonal antibody F023C5, determined to be more suitable than intact IgG and Fab fragments for immunoscintigraphy, were labeled with 131I or conjugated to DTPA for instant 111In-labeling, and administered i.v. (2-3 mCi/0.5 mg) to 509 patients in 11 nuclear medicine departments: 284 patients had gastrointestinal adenocarcinomas, 204 had nongastrointestinal adenocarcinomas and 21 were control; serum CEA was elevated in 169 patients, normal in 115, and not determined in 225. The following results were obtained: (a) no adverse reactions; (b) tumor imaging in 324 patients (in particular, in 81.5% CEA-seropositive and in 69.0% CEA-seronegative patients); (c) no significant difference in sensitivity among the results of the 11 departments; (d) no significant difference in overall sensitivity between 131I-and 111In-labeled immunoradiopharmaceuticals; (e) the fraction of documented lesions imaged was 73.3% in CEA-seropositive and 53.7% in CEA-seronegative patients; (f) the detection of liver metastases was hampered, particularly when using the 111In-labeled reagent, by nonspecific radioactivity uptake; (g) the major cause of negative immunoscintigraphy results was a lack of CEA in tumor lesions, as documented by immunohistochemistry; (h) lesion size is also important since the sensitivity was 64% for lesions up to 2 cm in diameter and 84% for larger lesions; (i) many "unexpected" radiolocalizations were recorded. Most were identified as occult tumor lesions. In 35 patients, this finding contributed to the early detection of tumor recurrences.
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癌症患者体内铟 111 标记的单克隆抗体的药代动力学。
DOI：
--
发表时间：
1985
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Hnatowich,DJ;Griffin,TW;Kosciuczyk,C;Rusckowski,M;Childs,RL;Mattis,JA;Shealy,D;Doherty,PW
通讯作者：
Doherty,PW
使用针对人高分子量黑色素瘤相关抗原的单克隆抗体的 123I、99mTc 和 111In 标记的 F(ab)2 片段进行免疫闪烁扫描。
DOI：
--
发表时间：
1984
期刊：
The Journal of nuclear medicine and allied sciences
影响因子：
--
作者：
Buraggi,GL;Callegaro,L;Turrin,A;Cascinelli,N;Attili,A;Emanuelli,H;Gasparini,M;Deleide,G;Plassio,G;Dovis,M
通讯作者：
Dovis,M
111In标记抗癌胚抗原单克隆抗体对结直肠癌的术前显像。
影响因子：
11.2
作者：
Beatty,JD;Duda,RB;Williams,LE;Sheibani,K;Paxton,RJ;Beatty,BG;Philben,VJ;Werner,JL;Shively,JE;Vlahos,WG
通讯作者：
Vlahos,WG
使用放射性标记单克隆抗体对黑色素瘤患者进行免疫闪烁显像的多中心研究。
影响因子：
11.2
作者：
Siccardi,AG;Buraggi,GL;Callegaro,L;Mariani,G;Natali,PG;Abbati,A;Bestagno,M;Caputo,V;Mansi,L;Masi,R
通讯作者：
Masi,R
使用 131I 标记的针对高分子量黑色素瘤相关抗原的单克隆抗体对黑色素瘤患者进行成像：完整免疫球蛋白及其 F(ab)2 片段的功效。
影响因子：
11.2
作者：
Buraggi,GL;Callegaro,L;Mariani,G;Turrin,A;Cascinelli,N;Attili,A;Bombardieri,E;Terno,G;Plassio,G;Dovis,M
通讯作者：
Dovis,M