Nanos2 suppresses meiosis and promotes male germ cell differentiation
Nanos2 suppresses meiosis and promotes male germ cell differentiation
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DOI：
10.1101/gad.1612708
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发表时间：
2008-02-15
影响因子：
10.5
通讯作者：
Saga, Yumiko
中科院分区：
文献类型：
--
作者：
Suzuki, Atsushi;Saga, Yumiko
在小鼠胚胎性腺中，视黄酸（RA）诱导雌性生殖细胞的减数分裂，而雄性生殖细胞由于Cyp26b1介导的RA代谢而从不进入减数分裂。我们在这里表明，Nanos2在男性生殖细胞的分化中起着关键作用。我们发现Nanos2通过阻止Stra8表达来维持减数分裂的抑制，Stra8是减数分裂前DNA复制所必需的，Cyp26b1减少后。我们还表明，Nanos2激活男性特异性的遗传程序，这是支持的减数分裂的抑制和诱导的男性型分化的女性生殖细胞后，强制表达的Nanos2。
in mouse fetal gonads, retinoic acid (RA) induces meiosis in the female germ cells, whereas the male germ cells never enter meiosis due to Cyp26b1-mediated RA metabolism. We show here that Nanos2 plays critical roles in the differentiation of male germ cells. We find that Nanos2 maintains the suppression of meiosis by preventing Stra8 expression, which is required for premeiotic DNA replication, after Cyp26b1 is decreased. We also demonstrate that Nanos2 activates a male-specific genetic program, which is supported by the inhibition of meiosis and the induction of male-type differentiation in female germ cells following the forced expression of Nanos2.