Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.
Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.
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迷走神经在清醒狗餐后反幽门协调中的作用。
DOI：
10.1152/ajpgi.00195.2004
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Takahashi,Toku
中科院分区：
文献类型：
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作者：
Ueno,Tomio;Uemura,Kenichiro;Harris,MaryB;Pappas,TheodoreN;Takahashi,Toku
一般认为，胃的固体排空是由胃窦和幽门之间的协调运动模式调节的。我们研究了迷走神经在调节胃窦和幽门之间的餐后协调中的作用。将力传感器植入7只狗的体浆膜表面、上颌窦、幽门和十二指肠。给狗喂食固体或液体食物，记录10小时内胃十二指肠的运动。用不透射线的标记物混合固体食物来评估胃排空。用六甲铵、ng -硝基-l-精氨酸甲酯（l-NAME）或短暂性迷走神经冷却阻断治疗。餐后运动模式有三个不同的阶段：早期、中期和晚期。在晚期，幽门深度舒张主要与巨大的胃窦收缩同步，这被定义为餐后幽门协调。一项胃排空研究显示胃内容物进入十二指肠的时间与幽门配合同时发生。迷走神经阻滞或六甲溴铵治疗可显著减少餐后胃窦收缩和晚期幽门舒张。l-NAME改变幽门运动模式，由松弛为主转为收缩为主。经六甲铵、l-NAME和迷走神经阻断治疗后，固体胃排空明显减弱。餐后进食流食后未见幽门协调。由此可见，餐后幽门协调在调节固体食物的胃排空中起重要作用。清醒犬的餐后幽门协调受迷走神经和氮能神经元的调控。
It is generally believed that gastric emptying of solids is regulated by a coordinated motor pattern between the antrum and pylorus. We studied the role of the vagus nerve in mediating postprandial coordination between the antrum and pylorus. Force transducers were implanted on the serosal surface of the body, antrum, pylorus, and duodenum in seven dogs. Dogs were given either a solid or a liquid meal, and gastroduodenal motility was recorded over 10 h. Gastric emptying was evaluated with radiopaque markers mixed with a solid meal. Dogs were treated with hexamethonium,NG-nitro-l-arginine methyl ester (l-NAME), or transient vagal nerve blockade by cooling. A postprandial motility pattern showed three distinct phases: early, intermediate, and late. In the late phase, profound pyloric relaxations predominantly synchronized with giant antral contractions that were defined as postprandial antropyloric coordination. A gastric emptying study revealed that the time at which gastric contents entered into the duodenum occurred concomitantly with antropyloric coordination. Treatment by vagal blockade or hexamethonium significantly reduced postprandial antral contractions and pyloric relaxations of the late phase.l-NAME changed pyloric motor patterns from relaxation dominant to contraction dominant. Solid gastric emptying was significantly attenuated by treatment with hexamethonium,l-NAME, and vagal blockade. Postprandial antropyloric coordination was not seen after feeding a liquid meal. It is concluded that postprandial antropyloric coordination plays an important role to regulate gastric emptying of a solid food. Postprandial antropyloric coordination is regulated by the vagus nerve and nitrergic neurons in conscious dogs.