In vivo magnetic resonance imaging of the effects of photodynamic therapy.
In vivo magnetic resonance imaging of the effects of photodynamic therapy.
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DOI：
10.1038/bjc.1989.244
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发表时间：
1989-08
影响因子：
8.8
通讯作者：
Wood, B
中科院分区：
文献类型：
--
作者：
Dodd, N J;Moore, J V;Poppitt, D G;Wood, B
核磁共振（NMR）质子成像和测量的参数T1和T2，已在体内进行小鼠乳腺肿瘤T50/80。肿瘤已治疗24小时前通过光动力疗法（PDT，使用血卟啉衍生物和630 nm激光）。质子图像清楚地在肿瘤最靠近入射光束的一侧划分出一个高信号强度区域，而肿瘤远离光束的部分与未经治疗的对照组的图像相似。T1和T2值在高强度区均升高。该高强度区域显示对应于PDT诱导的组织学坏死，低强度区域对应于组织学完整的肿瘤。对组织学测量的坏死深度与从NMR图像测量的“坏死深度”之间的关系进行线性回归分析，得出斜率为0.93（r2 = 0.95）。
Nuclear magnetic resonance (NMR) proton imaging and measurements of the parameters T1 and T2, have been carried out in vivo on the murine mammary tumour T50/80. Tumours had been treated 24 h previously by photodynamic therapy (PDT, using haematoporphyrin derivative and 630 nm laser light). Proton images clearly demarcated a high signal-intensity region on the side of the tumour closest to the incident light beam, while the parts of the tumour more remote from the beam resembled the images from untreated controls. Both T1 and T2 values were raised in the high-intensity region. This high-intensity region was shown to correspond to PDT-induced histological necrosis, the low-intensity region to histologically intact tumour. Linear regression analysis of the relationship of depth of necrosis measured histologically and 'depth of necrosis' measured from the NMR images, yielded a slope of 0.93 (r2 = 0.95).