Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.
Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.
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DOI：
10.1016/j.addr.2016.02.007
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发表时间：
2016-11-15
影响因子：
16.1
通讯作者：
Muzykantov V
中科院分区：
文献类型：
--
作者：
Villa CH;Anselmo AC;Mitragotri S;Muzykantov V
红细胞（RBC）作为生物或混合载体构成独特的药物递送系统，其能够极大地增强药代动力学、改变药效学（例如，通过改变血管内空间内的边缘化）和调节对附加货物的免疫应答。RBC药物递送系统的策略包括内部和表面负载，并且后者可以在离体和体内进行。RBC药物递送的一个相对较新的途径是它们作为纳米颗粒载体的应用。也正在努力将RBC的特征纳入纳米载体中，以模仿其最有用的方面，例如长循环和隐形特征。最近还探索了RBC作为递送抗原以调节免疫应答的载体。因此，基于RBC的药物递送系统代表了各种生物医学干预措施的超级载体，这反映在准备进入临床领域的几项工业和学术努力中。
Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to appended cargoes. Strategies for RBC drug delivery systems include internal and surface loading, and the latter can be performed both ex vivo and in vivo. A relatively new avenue for RBC drug delivery is their application as a carrier for nanoparticles. Efforts are also being made to incorporate features of RBCs in nanocarriers to mimic their most useful aspects, such as long circulation and stealth features. RBCs have also recently been explored as carriers for the delivery of antigens for modulation of immune response. Therefore, RBC-based drug delivery systems represent supercarriers for a diverse array of biomedical interventions, and this is reflected by several industrial and academic efforts that are poised to enter the clinical realm.