Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment.
Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment.
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DOI：
10.1038/s42003-022-04320-w
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发表时间：
2023-01-19
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
在复杂的、多时间和长度尺度的生物系统中，冗余赋予了鲁棒性和弹性，使其能够在动态环境条件下适应并提高生存能力；本文综述了由生物力学、生物物理和生物化学线索引发的细胞骨架重塑对干细胞机械适应和突发性谱系承诺的普遍影响。细胞骨架为细胞提供了适应性结构支架，在组织新生过程中调节干细胞结构-功能关系的出现，包括产前发育和产后愈合。识别和绘制有利于细胞骨架重塑和细胞适应的机械线索可能有助于建立环境背景，这些环境背景可以用作再生医学目标组织新生的翻译设计规范。在这篇综述中，我们总结了细胞骨架重塑在早期发育和出生后愈合过程中组织新生的背景下的发现，以及它在指导谱系承诺靶向组织再生中的相关性。我们强调细胞骨架靶向化学制剂如何调节干细胞分化，并在干细胞的新形态和功能中控制对机械线索的反应。我们进一步回顾了细胞骨架重构的时空可视化和测量方法，以及它对细胞力学特性的影响，作为一种适应功能。这些领域的研究可能会促进干细胞自身愈合潜力的转化，并改进再生医学材料、疗法和设备的设计。本文综述了早期发育和产后愈合过程中细胞骨骼重塑的生物力学、生物物理和生化调节剂，以用于靶向组织再生和再生医学应用。
Across complex, multi-time and -length scale biological systems, redundancy confers robustness and resilience, enabling adaptation and increasing survival under dynamic environmental conditions; this review addresses ubiquitous effects of cytoskeletal remodelling, triggered by biomechanical, biophysical and biochemical cues, on stem cell mechanoadaptation and emergent lineage commitment. The cytoskeleton provides an adaptive structural scaffold to the cell, regulating the emergence of stem cell structure-function relationships during tissue neogenesis, both in prenatal development as well as postnatal healing. Identification and mapping of the mechanical cues conducive to cytoskeletal remodelling and cell adaptation may help to establish environmental contexts that can be used prospectively as translational design specifications to target tissue neogenesis for regenerative medicine. In this review, we summarize findings on cytoskeletal remodelling in the context of tissue neogenesis during early development and postnatal healing, and its relevance in guiding lineage commitment for targeted tissue regeneration. We highlight how cytoskeleton-targeting chemical agents modulate stem cell differentiation and govern responses to mechanical cues in stem cells’ emerging form and function. We further review methods for spatiotemporal visualization and measurement of cytoskeletal remodelling, as well as its effects on the mechanical properties of cells, as a function of adaptation. Research in these areas may facilitate translation of stem cells’ own healing potential and improve the design of materials, therapies, and devices for regenerative medicine. This review highlights the biomechanical, biophysical, and biochemical modulators of cytoskeletal remodeling during tissue neogenesis in early development and postnatal healing for targeted tissue regeneration and regenerative medicine applications.
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影响因子：
16.6
作者：
Andreu I;Falcones B;Hurst S;Chahare N;Quiroga X;Le Roux AL;Kechagia Z;Beedle AEM;Elosegui-Artola A;Trepat X;Farré R;Betz T;Almendros I;Roca-Cusachs P
通讯作者：
Roca-Cusachs P
影响因子：
8.2
作者：
Allan C;Ker A;Smith CA;Tsimbouri PM;Borsoi J;O'Neill S;Gadegaard N;Dalby MJ;Dominic Meek RM
通讯作者：
Dominic Meek RM
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R
影响因子：
2.4
作者：
Arnsdorf, Emily J.;Tummala, Padmaja;Castillo, Alesha B.;Zhang, Fan;Jacobs, Christopher R.
通讯作者：
Jacobs, Christopher R.
影响因子：
7.2
作者：
Andrade, Daniel;Rosenblatt, Jody
通讯作者：
Rosenblatt, Jody