A generalized dose-response relationship for adenovirus infection and illness by exposure pathway
A generalized dose-response relationship for adenovirus infection and illness by exposure pathway
复制标题
腺病毒感染和疾病（按暴露途径）的广义剂量反应关系
作者：
P. Teunis;J. Schijven;S. Rutjes
腺病毒在环境中随处可见，并引起各种健康问题，包括肠道疾病和呼吸道疾病的症状。尽管它们对公共卫生具有重要意义，但很少有研究涉及与暴露于腺病毒相关的健康风险。已经发表了一些腺病毒的人体挑战研究，涉及通过口服、吸入、鼻内和眼内液滴接种的暴露。尽管这些暴露导致不同的症状，但感染可定义为相应粘膜的定植。建立了一个两水平的剂量-反应模型，用于描述腺病毒各种攻击研究中感染性和致病性的分布，将接种途径的差异作为平均感染性和致病性的变化。该剂量-反应模型可用于预测腺病毒的感染性，具体到四种研究的接种方法中的任何一种。感染和急性疾病的广义腺病毒剂量-反应关系考虑了不同腺病毒类型之间感染性和/或致病性的变化，以及由于数据有限而导致的不确定性。
SUMMARY Adenoviruses are found everywhere in the environment, and cause various health problems including symptoms of enteric illness, and respiratory illness. Despite their significance to public health, few studies have addressed the health risks associated with exposure to adenovirus. Human challenge studies have been published for a few adenoviruses, which involved exposure through oral ingestion, inhalation, intranasal and intraocular droplet inoculation. Nothwithstanding the different symptoms resulting from such exposures, infection can be defined as colonization of a corresponding mucosa. A two-level dose-response model was developed to describe the distributions of infectivity and pathogenicity in various challenge studies of adenovirus, incorporating differences in inoculation route as shift in average infectivity and pathogenicity. This dose-response model can be used to make predictions for the infectivity of adenovirus, specific to any of the four studied inoculation methods. The generalized adenovirus dose-response relationship for infection and acute illness takes into account variation in infectivity and/or pathogenicity across adenovirus types, as well as uncertainty due to limited data.
影响因子：
11.8
作者：
Gray, Gregory C.;McCarthy, Troy;Erdman, Dean D.
通讯作者：
Erdman, Dean D.