Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000
Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000
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DOI：
10.1016/j.amjmed.2003.11.025
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发表时间：
2004-05-01
影响因子：
5.9
通讯作者：
Tu, JV
中科院分区：
文献类型：
--
作者：
Lee, DS;Mamdani, MM;Tu, JV
目得：回顾加拿大安大略老年心力衰竭患者的药物治疗趋势和伴随结果。方法：从1992年4月至2000年3月，对77，421例老年（年龄大于或等于65岁）社区心力衰竭患者的药物治疗使用、死亡率和再住院率进行了测定。使用链接的管理数据库。从已发表的荟萃分析和随机试验中确定治疗效果。结果：从1992年到2000年，血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂的使用从58%增加到62%（P = 0.001），而β受体阻滞剂的使用从6%增加到22%（P
PURPOSE: To review trends in drug therapy and concomitant outcomes of elderly heart failure patients in Ontario, Canada.METHODS: Utilization of drug therapies, mortality, and re-hospitalization rates from April 1992 to March 2000 were determined in 77,421 elderly (aged greater than or equal to65 years), community-based heart failure patient!; using linked administrative databases. Treatment effects were identified from published meta-analyses and randomized trials. The effect of drug trends on mortality and morbidity were assessed based on their absolute treatment effects.RESULTS: From 1992 to 2000, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use increased from 58% to 62% (P = 0.001) while beta-blocker use increased from 6% to 22% (P