Working for food shifts nocturnal mouse activity into the day.
Working for food shifts nocturnal mouse activity into the day.
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为食物而工作将夜间小鼠活动转移到一天。
DOI：
10.1371/journal.pone.0017527
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发表时间：
2011-03-30
期刊：
影响因子：
3.7
通讯作者：
Daan S
中科院分区：
文献类型：
--
作者：
Hut RA;Pilorz V;Boerema AS;Strijkstra AM;Daan S
夜间活动的啮齿动物在白天的食物获取被限制在几个小时时表现出全天的食物预期活动。定时获取食物也会导致食物摄入减少，但食物摄入在昼夜节律组织中的作用本身尚未得到描述。通过模拟为食物而工作的老鼠的自然食物短缺，我们表明，仅减少食物摄入量就会将活动阶段从夜间转移到白天，并最终导致夜间麻木（自然体温过低）。将其释放到持续的黑暗中，并随意进食，会立即导致活动逆转到之前的夜间阶段，这表明经典的昼夜节律起搏器保持了其光-暗周期的阶段。这种行为时间的灵活性将允许小鼠在自然条件恶劣的情况下利用昼夜时间生态位，同时最大限度地减少能量消耗。这项研究揭示了新陈代谢和哺乳动物昼夜节律组织之间的密切联系。
Nocturnal rodents show diurnal food anticipatory activity when food access is restricted to a few hours in daytime. Timed food access also results in reduced food intake, but the role of food intake in circadian organization per se has not been described. By simulating natural food shortage in mice that work for food we show that reduced food intake alone shifts the activity phase from the night into the day and eventually causes nocturnal torpor (natural hypothermia). Release into continuous darkness with ad libitum food, elicits immediate reversal of activity to the previous nocturnal phase, indicating that the classical circadian pacemaker maintained its phase to the light-dark cycle. This flexibility in behavioral timing would allow mice to exploit the diurnal temporal niche while minimizing energy expenditure under poor feeding conditions in nature. This study reveals an intimate link between metabolism and mammalian circadian organization.