Invited Commentary: Relationship Between Ovulation and Markers of Systemic Inflammation Versus Markers of Localized Inflammation.
Invited Commentary: Relationship Between Ovulation and Markers of Systemic Inflammation Versus Markers of Localized Inflammation.
复制标题
特邀评论：排卵与全身炎症标志物与局部炎症标志物之间的关系。
DOI：
10.1093/aje/kwz265
复制
发表时间：
2020
影响因子：
5
通讯作者：
Schildkraut,JoellenM
中科院分区：
文献类型：
--
作者：
Schildkraut,JoellenM
在这一期的《美国流行病学杂志》上，黄等人（美国流行病学杂志）。二○二○年; 189（7）：660-670）报道了一生排卵年数（LOY）和C-反应蛋白（CRP）循环水平之间的反比关系，与他们的假设相反。CRP是慢性炎症的非特异性全身性标志物，并且有证据表明，通过CRP测量的全身性炎症还有其他驱动因素。也有大量证据支持排卵可能是局部炎症反应的原因。由于卵巢癌是女性癌症死亡的第五大常见原因，因此迫切需要预防策略。本报告的发现强调了需要新的研究计划来确定持续排卵和卵巢癌风险之间的关系，以确定致癌机制。
In this issue of theAmerican Journal of Epidemiology, Huang et al. (Am J Epidemiol. 2020;189(7):660–670) report an inverse relationship between lifetime ovulatory years (LOY) and circulating levels of C-reactive protein (CRP), counter to their hypothesis. CRP is a nonspecific systemic marker of chronic inflammation, and there is evidence that there are other drivers of systemic inflammation as measured by CRP. There also is a body of evidence supporting the possibility that ovulation may be responsible for a localized inflammatory response. Because ovarian cancer is the fifth most common cause of cancer death in women, preventive strategies are urgently needed. The findings of this report underscore the need for new research initiatives to determine the relationship between incessant ovulation and ovarian cancer risk in order to identify mechanisms of carcinogenesis.