Parathyroid hormone (1-34) increases the density of rat cancellous bone in a bone chamber - A dose-response study
Parathyroid hormone (1-34) increases the density of rat cancellous bone in a bone chamber - A dose-response study
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DOI：
10.1302/0301-620x.82b1.9729
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发表时间：
2000-01-01
影响因子：
--
通讯作者：
Aspenberg, P
中科院分区：
文献类型：
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作者：
Skripitz, R;Andreassen, TT;Aspenberg, P
甲状旁腺激素（PTH）的间歇治疗对完整的松质骨和皮质骨有合成代谢作用。关于PTH的施用对骨折愈合或骨科植入物的结合的影响知之甚少。我们研究了在大鼠胫骨干骺端近中端植入的钛室中骨痂的自发向内生长和骨形成。四组10只体重约350 g的雄性大鼠分别以0、15、60或240 μ g/kg/天的剂量注射人PTH（1-34），从植入室的当天起持续42天，在观察期间，室仅部分地被骨痂和骨填充，并且未发现各组之间的向内生长距离有差异。在以15、60或240 μ g/kg/天剂量给予PTR的组中，松质骨密度分别增加90%、132%和173%。骨密度与PTH剂量的对数呈线性相关（r（2）= 0.6）。我们的研究结果表明，PTH治疗可能具有增强骨科植入物结合的潜力，并在低剂量时对骨折愈合具有有益作用。
Intermittent treatment with parathyroid hormone (PTH) has has an anabolic effect on bath intact cancellous and cortical bone. Very little is known about the effect of the administration off PTH on the healing of fractures or the incorporation of orthopaedic implants. We have investigated the spontaneous ingrowth of callus and the formation of bone in a titanium chamber implanted at the medioproximal aspect of the tibial metaphysis of the rat. Four groups of ten male rats weighing approximately 350 g were injected with human PTH (1-34) in a dosage of 0, 15, 60 or 240 mu g/kg/day, respectively, for 42 days from the day of implantation of the chamber.During the observation period the chamber became only partly filled with callus and bone and no difference in ingrowth distance into the chamber was found between the groups, The cancellous density was increased by 90%, 132% and 173% in the groups given PTR in a dosage of 15, 60 or 240 mu g/kg/day, respectively. There clp as a linear correlation between bone density and the log PTH doses (r(2) = 0.6),Our findings suggest that treatment with PTH may have a potential for enhancement of the incorporation of orthopaedic implants as well as a beneficial effect on the healing of Fractures when it is given in low dosages.