Building Bridges from Genome to Phenome: Molecules, Methods and Models—An Introduction to the Symposium
Building Bridges from Genome to Phenome: Molecules, Methods and Models—An Introduction to the Symposium
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搭建从基因组到表型组的桥梁：分子、方法和模型——研讨会简介
DOI：
10.1093/icb/icaa073
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发表时间：
2020
影响因子：
2.6
通讯作者：
Stillman, Jonathon H
中科院分区：
文献类型：
--
作者：
Burnett, Karen G;Durica, David S;Mykles, Donald L;Stillman, Jonathon H
稳定的基因型如何与其环境相互作用，以产生表型变异，可以采取行动的进化和生态力量是一个中心的研究重点，在SICB内代表的许多科学学科。搭建桥梁研讨会汇集了科学家使用各种生物体，方法和生物组织水平来研究基因组的涌现特性。与专题讨论会有关的讲习班旨在确定这一领域研究的前沿和主要障碍，并就可能加快进展步伐的未来方向提出建议。包括在这个研讨会卷的论文提请注意在非模式生物中使用比较方法来研究基因型-环境相互作用的许多方面，驱动表型变异的优势。这些贡献和最后的白色文件也说明了需要新的概念框架，可以桥接和容纳数据和结论，从广泛的研究系统采用比较和综合生物学家解决基因组表型问题。
How stable genotypes interact with their environment to generate phenotypic variation that can be acted upon by evolutionary and ecological forces is a central focus of research across many scientific disciplines represented within SICB. The Building Bridges Symposium brought together scientists using a variety of organisms, methods, and levels of biological organization to study the emergent properties of genomes. Workshops associated with the Symposium aimed to identify the leading edges and major barriers to research in this field, and to recommend future directions that might accelerate the pace of progress. The papers included in this Symposium volume draw attention to the strength of using comparative approaches in non-model organisms to study the many aspects of genotype–environment interaction that drive phenotype variation. These contributions and the concluding white paper also illustrate the need for novel conceptual frameworks that can bridge and accommodate data and conclusions from the broad range of study systems employed by comparative and integrative biologists to address genome-to-phenome questions.
不良结果途径 (AOP) 概念在毒理学中实现基因组到表型组发现的示例。
影响因子：
2.6
作者：
K. Gust;Qing Ji;Xiao Luo
通讯作者：
Xiao Luo
影响因子：
2.6
作者：
Carneiro VC;Lyko F
通讯作者：
Lyko F