Fish in a Dish: Drug Discovery for Hearing Habilitation.
Fish in a Dish: Drug Discovery for Hearing Habilitation.
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DOI：
10.1016/j.ddmod.2012.02.001
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Rubel, Edwin W
中科院分区：
文献类型：
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作者：
Esterberg, Robert;Coffin, Allison B;Ou, Henry;Simon, Julian A;Raible, David W;Rubel, Edwin W
大多数听力损失是由内耳毛细胞的永久性丧失引起的。在哺乳动物模型中检测这种复杂现象的困难常常阻碍了对调节毛细胞损失或刺激其再生的易感性的药物的鉴定。斑马鱼已经成为许多情况下化学筛选的强大动物模型。斑马鱼的几个特征，如其小尺寸和感觉毛细胞的外部位置，独特地将其定位为研究毛细胞毒性，保护和再生的理想模式生物。我们使用这个模型来筛选影响毛细胞生物学各个方面的药物，并确定了影响这些过程的化合物。这些药物和药物样化合物的鉴定有望在未来阻止人类听力损失的能力。
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several characteristics of the zebrafish, such as its small size and external location of sensory hair cells, uniquely position it as an ideal model organism for the study of hair cell toxicity, protection, and regeneration. We have used this model to screen for drugs that affect each of these aspects of hair cell biology and have identified compounds that affect each of these processes. The identification of such drugs and drug-like compounds holds promise in the future ability to stem hearing loss in the human population.