Evaluation of an integrated orbital tissue expander in an anophthalmic feline model.
Evaluation of an integrated orbital tissue expander in an anophthalmic feline model.
复制标题
在无眼猫科动物模型中评估集成眼眶组织扩张器。
DOI：
10.1016/j.ajo.2006.10.028
复制
发表时间：
2007
影响因子：
4.2
通讯作者：
Parel,Jean-Marie
中科院分区：
文献类型：
--
作者：
Tse,DavidT;Pinchuk,Leonard;Davis,Stewart;Falcone,StevenF;Lee,Wendy;Acosta,AnaCaroline;Hernandez,Eleut;Lee,Elizabete;Parel,Jean-Marie
目的评价综合眶组织扩张器（OTE）用于促进眼无窝骨生长的解剖效果和组织生物相容性。设计在猫身上进行了一项动物研究，以评估有和没有OTE的眶骨生长情况。方法OTE是一个充气（0.5 ~ 6.0 cm3）的聚合物球体，滑动在钛T板上，用螺钉固定在眶外侧缘。8只猫在两周大的时候进行了左眼摘除，其中5只接受了OTE手术，其余3只作为未植入的对照组。通过将生理盐水注入OTE至最终容积为3.5 ml，进行连续经结膜种植体膨胀。获得连续计算机断层扫描以评估窝生长情况。所有8只猫在18周时被安乐死，并准备了干燥的头骨。有效眶体积是通过在干燥颅骨的眶内充气一个OTE来测量的，直到它完全填满腔。结果3只猫周期性地抓开结膜和结膜，导致OTE破裂，导致种植体置换。在18周时，OTE扩张的眼眶体积比正常对侧小约18%。在对照动物中，无眼眼眶体积比对侧眼眶小约66%。眼眶组织病理检查未见异物反应。结论：这项概念验证的初步研究证明了种植体在猫身上的有效性，并且没有观察到与种植体相关的不良反应。OTE有可能刺激人类无眼眼窝的骨生长。
PURPOSETo evaluate the anatomical effects and tissue biocompatibility in a feline model of an integrated orbital tissue expander (OTE) designed to stimulate bone growth in an anophthalmic socket.DESIGNAn animal study was performed in cats to assess orbital bone growth with and without an OTE.METHODSThe OTE is an inflatable (0.5 to >6.0 cm3) polymeric globe sliding on a titanium T plate secured to the lateral orbital rim with screws. Eight cats had left eye enucleation at age two weeks, with five orbits receiving an OTE and the remaining three serving as nonimplanted controls. Serial transconjunctival implant inflation was performed by injecting normal saline solution into the OTE to a final volume of 3.5 ml. Serial computed tomographic scans were obtained to assess socket growth. All eight cats were euthanized at 18 weeks and dry skulls prepared. The effective orbital volume was measured by inflating an OTE in the orbit of a dry skull until it filled the cavity completely.RESULTSThree cats periodically scratched open the tarsorrhaphy and conjunctiva to rupture the OTE, which resulted in implant exchanges. At 18 weeks, the OTE expanded orbital volume was approximately 18% smaller than the normal contralateral side. In the control animals, the anophthalmic orbital volume was approximately 66% smaller than the contralateral orbit. Histopathology of orbital tissues showed no evidence of foreign body reaction.CONCLUSIONSThis proof-of-concept pilot study demonstrated implant efficacy in cats, and no implant-related adverse effects were observed. OTE has the potential to stimulate bone growth in human anophthalmic orbits.