Synthesis of cyclic proline-containing peptides via ring-closing metathesis.
Synthesis of cyclic proline-containing peptides via ring-closing metathesis.
复制标题
通过闭环复分解合成含环状脯氨酸的肽。
作者：
P. Harris;M. Brimble;P. Gluckman
[反应：见正文]已经制备了几个嵌入在含有脯氨酸的双肽和三肽中的二烯，并进行了闭环复分解。制备了具有明确的酰胺构型和不同环大小的双环肽。揭示了环化步骤的几个局限性。
[reaction: see text] Several dienes embedded in di- and tripeptides which incorporate proline have been prepared and subjected to ring-closing metathesis. Bicyclic peptides of well-defined amide geometry and of varying ring sizes were prepared. Several limitations of the cyclization step were revealed.