Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory
Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory
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DOI：
10.1016/j.neulet.2006.06.044
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发表时间：
2006-09-11
影响因子：
2.5
通讯作者：
Schroder, Nadja
中科院分区：
文献类型：
--
作者：
de Lima, Maria Noemia;Luft, Tatiana;Schroder, Nadja
海马在新物体识别（NOR）记忆中的作用仍然存在争议。在这里，我们报告的发现，背侧海马是必不可少的巩固NOR记忆高达3它训练后。暂时失活的背侧海马与双侧海马内注入蝇蕈醇立即或3小时，但不6小时后训练受损的24小时NOR保留在雄性大鼠。这些结果强烈表明，背侧海马所需的早期和延迟NOR巩固。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The role of the hippocampus in novel object recognition (NOR) memory remains controversial. Here we report the finding that the dorsal hippocampus is essential for consolidation of NOR memory up to 3 It after training. Temporary inactivation of the dorsal hippocampus with a bilateral intrahippocampal infusion of muscimol immediately or 3 h, but not 6 h post-training impaired 24-h NOR retention in male rats. These results strongly indicate that the dorsal hippocampus is required for early and delayed NOR consolidation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.