ELECTRORETINOGRAM - ITS COMPONENTS AND THEIR ORIGINS
ELECTRORETINOGRAM - ITS COMPONENTS AND THEIR ORIGINS
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DOI：
10.1016/0042-6989(68)90041-2
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发表时间：
1968-01-01
期刊：
影响因子：
1.8
通讯作者：
BROWN, KT
中科院分区：
文献类型：
--
作者：
BROWN, KT
哺乳动物视网膜电图（electroretinogram）的三个主要神经成分被证明，包括晚期RP（受体电位）、b波和直流成分。这些都给出了一个适当的解释的所有主要功能的锥ERG。视杆ERG的主要特征由这3个相同的成分加上来自色素上皮的c波来解释。视锥和视杆ERG中的不同形式的关反应现在很容易从视锥晚期RP的快速衰减中理解，与视杆晚期RP的慢得多的衰减相比。产生晚期RP和c波的细胞已被确定，b波和d.c.成分已被定位于内核层，但产生这些后一种成分的细胞类型尚未确定。除了主要成分外，还发现了一些次要成分，这些成分有助于ERG的详细形式。这些组件仍在被发现，这一过程可能会继续下去。其中，只有双相早期RP和直接诱发的三相反应的色素上皮细胞已被确定为特定的细胞类型。除了将ERG分析成组分，并确定每个组分的细胞来源外，确定每个组分在视网膜功能中的作用尤为重要。ERG工作的这一进一步阶段才刚刚开始，因为存在与色素上皮的受体和细胞一起鉴定的成分。
Three major neural components of the mammalian ERG [electroretinogram] were demonstrated, including the late RP (receptor potential), b-wave, and d.c. component. These give an adequate explanation of all main features of the cone ERG. Main features of the rod ERG are accounted for by these same 3 components, plus the c-wave from the pigment epithelium. Different forms of the off-responses in cone and rod ERGs are now readily understood from the rapid decay of the cone late RP, compared with the much slower decay of the rod late RP. The generating cells have been identified for the late RP and c-wave, and b-wave and d.c. component have been localized to the inner nuclear layer, but the cell types which generate these latter components have not been identified. In addition to the major components, a number of minor components have been found which contribute to the detailed form of the ERG. Such components are still being discovered, and this process may continue. Among these, only the biphasic early RP and the directly-evoked triphasic response of the pigment epithelium cells have been positively identified with particular cell types. In addition to analyzing the ERG into components, and determining the cellular origin of each component, it is especially important to determine the role of each component in retinal functions. This further phase of ERG work is just beginning, since there are components which are identified with both the receptors and cells of the pigment epithelium.