Oral Probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants
Oral Probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants
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DOI：
10.1542/peds.2004-1463
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发表时间：
2005-01-01
期刊：
影响因子：
8
通讯作者：
Oh, W
中科院分区：
文献类型：
--
作者：
Lin, HC;Su, BH;Oh, W
目标。我们评价了益生菌在降低极低出生体重(VLBW)婴儿坏死性小肠结肠炎(NEC)发生率和严重程度方面的效果。采用前瞻性、隐蔽性、随机对照试验，评价益生菌在降低极低出生体重儿(=2期)NEC发生率和严重程度方面的有益作用。共有367名婴儿参加，其中研究组180名，对照组187名。两组的人口统计学和临床变量相似。研究组死亡或NEC(=2期)的发生率显著较低(9/180比24/187)。与对照组相比，NEC(>；=2期)的发生率也显著降低(180例中有2例，187例中有10例)。对照组有6例重度NEC(Bell分期3)，研究组无1例。血培养阳性者均未检出乳杆菌或双歧杆菌。Infloran作为益生菌与母乳一起肠道喂养可降低极低出生体重儿NEC的发生率和严重程度。
Objective. We evaluated the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants.Patients and Methods. A prospective, masked, randomized control trial was conducted to evaluate the beneficial effects of probiotics in reducing the incidence and severity of NEC among VLBW (= stage 2).Results. Three hundred sixty-seven infants were enrolled: 180 in the study group and 187 in the control group. The demographic and clinical variables were similar in both groups. The incidence of death or NEC (>= stage 2) was significantly lower in the study group (9 of 180 vs 24 of 187). The incidence of NEC (>= stage 2) was also significantly lower in the study when compared with the control group (2 of 180 vs 10 of 187). There were 6 cases of severe NEC (Bell stage 3) in the control group and none in the study group. None of the positive blood culture grew Lactobacillus or Bifidobacterium species.Conclusion. Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.