Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amiloride, in essential hypertension
Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amiloride, in essential hypertension
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噻吗洛尔和氢氯噻嗪，或氢氯噻嗪和阿米洛利对原发性高血压的长期影响
DOI：
10.1007/bf00645129
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发表时间：
1977
影响因子：
2.9
通讯作者：
H. Castenfors
中科院分区：
文献类型：
--
作者：
H. Castenfors
24例轻度至中度高血压患者接受氢氯噻嗪和安慰剂、噻吗洛尔或噻吗洛尔和阿米洛利治疗长达60周。双盲试验评价了氢氯噻嗪中加入噻吗洛尔和阿米洛利的效果。在24例患者中，22例患者的仰卧位舒张压低于或等于95 mm Hg，由氢氯噻嗪和噻吗洛尔产生。用阿米洛利代替钾补充剂增加了抗高血压效果。
SummaryTwenty-four patients with mild to moderate hypertension were treated for up to 60 weeks with hydrochlorothiazide and either placebo, timolol, or timolol and amiloride. The effect of adding timolol and amiloride to hydrochlorothiazide was evaluated in a double blind trial. In 22 of the 24 patients a supine diastolic blood pressure below or equal to 95 mm Hg was produced by hydrochlorothiazide and timolol. Replacing a potassium supplement with amiloride increased the antihypertensive effect.