Acute anti-inflammatory activity of four saponins isolated from ivy:: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema
Acute anti-inflammatory activity of four saponins isolated from ivy:: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema
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DOI：
10.1016/j.phymed.2004.04.005
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发表时间：
2005-06-01
期刊：
影响因子：
7.9
通讯作者：
Elias, R
中科院分区：
文献类型：
--
作者：
Gepdiremen, A;Mshvildadze, V;Elias, R
研究了秋水仙α - Hedera - Hedera - Hedera - Hedera - desmo苷和hederasaponin-C以及hederacolchisides-E和-F （bidesmo苷）对卡拉胶诱导的大鼠急性足跖水肿的抗炎作用。口服皂苷和吲哚美辛，浓度分别为0.02和20 mg/kg体wt。在急性炎症的第一阶段，吲哚美辛是最有效的药物。a-hederin和hederasaponin-C无效，hederacolchisides-E和-F在第一期有轻微的抗炎作用。对于急性炎症的第二阶段，吲哚美辛和hederaccolidide - f被确定为非常有效的化合物。A-hederin在第二阶段也被发现无效。尽管发现hederasaponin-C和-E在炎症的第二阶段有效，但它们不如吲哚美辛和hederacolchiside-F有效。因此，hederasaponin-C， -E和-F可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。后一种影响可能通过影响前列腺素途径发生。从构效关系来看，C-3位置的糖和C-28位置的Rha7-Glc1-6Glc片段可能是急性抗炎作用所必需的。(c) 2005 Elsevier GmbH版权所有。
The anti-inflammatory potential of alpha-hederin (monodesmoside) and hederasaponin-C from Hedera helix, and hederacolchisides-E and -F (bidesmosides) from H. colchica was investigated in carrageenan-induced acute paw edema in rats. Saponins and indomethacin were given orally in concentrations of 0.02 and 20 mg/kg body wt. For the first phase of acute inflammation, indomethacin was found as the most potent drug. a-hederin and hederasaponin-C were found ineffective, while hederacolchisides-E and -F showed slight anti-inflammatory effects on the first phase. For the second phase of acute inflammation, indomethacin and hederacolchiside-F were determined as very potent compounds. a-hederin was found ineffective for the second phase, either. Despite hederasaponin-C and -E were found effective in the second phase of inflammation, they were not found as effective as indomethacin and hederacolchiside-F. As a conclusion, hederasaponin-C, -E and -F, may exert their anti-inflammatory effects by blocking bradykinin or other inflammation mediators. The latter affect may occur via affecting prostaglandin pathways. Regarding the structure activity relationship, it is likely that sugars at C-3 position and Rha7-Glc1-6Glc moiety at C-28 position are essential for the acute anti-inflammatory effect. (c) 2005 Elsevier GmbH. All rights reserved.