Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection
Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection
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DOI：
10.3748/wjg.v18.i18.2225
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发表时间：
2012-05-14
影响因子：
4.3
通讯作者：
Ishikawa, Chie
中科院分区：
文献类型：
--
作者：
Mori, Naoki;Nakasone, Kazunori;Ishikawa, Chie
目的：评价褐藻多糖硫酸酯（一种从海藻中提取的复合硫酸多糖）在体外和体内对丙型肝炎病毒（HCV）RNA载量的影响。方法：将从日本冲绳培养的枝管冈村藻中获得的褐藻多糖硫酸酯存在下培养表达HCV-1b复制子的细胞，并定量HCV复制水平。在一项开放标签非对照研究中，15例慢性丙型肝炎、HCV相关肝硬化和肝细胞癌患者接受褐藻糖胶（0.83 g/d）治疗12个月。结果：褐藻糖胶剂量依赖性地抑制HCV复制子的表达。在用岩藻依聚糖治疗8-10个月时，HCV RNA水平相对于基线显著降低。同样的治疗也倾向于降低血清丙氨酸氨基转移酶水平，后者与HCV RNA水平相关。然而，实验室检查的改善并没有转化为显著的临床改善。结论：褐藻糖胶治疗HCV相关慢性肝病安全有效。需要进一步的对照临床试验来证实目前的研究结果。(C)2012年百世登。All rights reserved.
AIM: To evaluate the effects of fucoidan, a complex sulfated polysaccharide extract from marine seaweed, on hepatitis C virus (HCV) RNA load both in vitro and in vivo.METHODS: HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa, Japan, and quantified the level of HCV replication. In an open-label uncontrolled study, 15 patients with chronic hepatitis C, and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan (0.83 g/d) for 12 mo. The clinical symptoms, biochemical tests, and HCV RNA levels were assessed before, during, and after treatment.RESULTS: Fucoidan dose-dependently inhibited the expression of HCV replicon. At 8-10 mo of treatment with fucoidan, HCV RNA levels were significantly lower relative to the baseline. The same treatment also tended to lower serum alanine aminotransferase levels, and the latter correlated with HCV RNA levels. However, the improved laboratory tests did not translate into significant clinical improvement. Fucoidan had no serious adverse effects.CONCLUSION: Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCV-related chronic liver diseases. Further controlled clinical trials are needed to confirm the present findings. (C) 2012 Baishideng. All rights reserved.