Pathologic stage migration has slowed in the late PSA era
Pathologic stage migration has slowed in the late PSA era
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DOI：
10.1016/j.urology.2007.09.001
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发表时间：
2007-11-01
期刊：
影响因子：
2.1
通讯作者：
Klein, Eric A.
中科院分区：
文献类型：
--
作者：
Dong, Fel;Reuther, Alwyn M.;Klein, Eric A.
血清前列腺特异性抗原（PSA）筛查导致临床和病理分期迁移。我们检查了1987年至2005年之间的根治性直肠癌切除术治疗的患者，以建立病理分期迁移的时间趋势，评估患者的比例与非器官局限性疾病（NOCD）。结果从1987年到2005年，中国人群经历了向更多器官局限性肿瘤的病理分期迁移（P
OBJECTIVES Serum prostate specific antigen (PSA) screening has led to clinical and pathologic stage migration. We examined patients treated by radical prostatectomy between 1987 and 2005 to establish temporal trends in pathologic stage migration as assessed by the proportion of patients with nonorgan-confined disease (NOCD).METHODS Step-sectioned prostatectomy specimens of 3364 consecutively treated patients were evaluated by year. The data were modeled by joinpoint regression, and the optimal model was selected by a Bayesian information criterion.RESULTS From 1987 to 2005, the population underwent pathologic stage migration toward more organ-confined tumors (P