Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry
Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry
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DOI：
10.1053/jcpa.2002.0630
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发表时间：
2003-05-01
影响因子：
0.8
通讯作者：
Papparella, S
中科院分区：
文献类型：
--
作者：
Restucci, B;Maiolino, P;Papparella, S
血管生成有助于提供增殖细胞的营养和呼吸需求，对肿瘤生长至关重要。血管生成控制是复杂的，涉及细胞因子网络，特别是血管内皮生长因子（VEGF），一种也刺激肿瘤细胞增殖的有效内皮细胞有丝分裂原。本研究的目的是评估VEGF的表达和微血管密度（每毫米微血管数），在犬乳腺癌。VEGF的表达和微血管密度高于正常睾丸组织中的腺瘤，这两个参数都高于弥漫性肿瘤比在小管内肿瘤。这些数据表明，在更恶性的组织学类型的睾丸肿瘤血管生成的增加，并建议，VEGF和微血管密度是有用的标准，用于评估犬睾丸肿瘤的内在恶性和生长潜力。(C)2003爱思唯尔科技有限公司版权所有。
Angiogenesis, which assists in supplying the nutritional and respiratory needs of proliferating cells, is essential for tumour growth. Angiogenic control is complex, involving a network of cytokines, in particular vascular endothelial growth factor (VEGF), a potent endothelial cell mitogen which also stimulates neoplastic cell proliferation. The purpose of this study was to evaluate VEGF expression and microvessel density (number of microvessels per mm), in canine seminomas. VEGF expression and microvessel density were higher in seminomas than in normal testicular tissue; both parameters were higher in diffuse tumours than in intratubular tumours. These data demonstrate an increase in angiogenesis in the more malignant histological types of seminoma and suggest that both VEGF and microvessel density are useful criteria for evaluating the intrinsic malignancy and growth potential of canine testicular tumours. (C) 2003 Elsevier Science Ltd. All rights reserved.