Positron Emission Tomography Imaging of D2/3 Agonist Binding in Healthy Human Subjects With the Radiotracer [11C]-N-Propyl-Norapomorphine: Preliminary Evaluation and Reproducibility Studies
Positron Emission Tomography Imaging of D2/3 Agonist Binding in Healthy Human Subjects With the Radiotracer [11C]-N-Propyl-Norapomorphine: Preliminary Evaluation and Reproducibility Studies
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DOI：
10.1002/syn.20633
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发表时间：
2009-07-01
期刊：
影响因子：
2.3
通讯作者：
Mathis, Chester A.
中科院分区：
文献类型：
--
作者：
Narendran, Rajesh;Frankle, W. Gordon;Mathis, Chester A.
Objective: (-)-N-[C-11]-propyl-norapomorphine (NPA) is a full dopamine D-2/3 receptor agonist radiotracer suitable for imaging D-2/3 receptors configured in a state of high affinity for agonists using positron emission tomography. The aim of the present study was to define the optimal analytic method to derive accurate and reliable D-2/3 receptor parameters with [C-11]NPA. Methods: Six healthy subjects (four females/two males) underwent two [C-11]NPA scans in the same day. D-2/3 receptor-binding parameters were estimated using kinetic analysis (using one- and two-tissue compartment models) as well as simplified reference tissue method in the three functional subdivisions of the striatum (associative striatum, limbic striatum, and sensorimotor striatum). The test-retest variability and intraclass correlation coefficient were assessed for distribution volume (V-T), binding potential relative to plasma concentration (BPP), and binding potential relative to nondisplaceable uptake (BPND). Results: A two-tissue compartment kinetic model adequately described the functional subdivisions of the striatum as well as cerebellum time-activity data. The reproducibility of V-T, was excellent (
