Brain T1 intensity changes after levodopa administration in healthy subjects: a voxel-based morphometry study
Brain T1 intensity changes after levodopa administration in healthy subjects: a voxel-based morphometry study
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DOI：
10.1111/j.1365-2125.2006.02695.x
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发表时间：
2006-11-01
影响因子：
3.4
通讯作者：
Blin, Olivier
中科院分区：
文献类型：
--
作者：
Salgado-Pineda, Pilar;Delaveau, Pauline;Blin, Olivier
目的研究左旋多巴（左旋多巴）对人大脑局部注视区T1信号的影响。采集矩阵= 256 x 192 x 104;重构矩阵= 256 × 256 × 128），我们通过基于体素的形态测定法（VBM）检测了单次给予100 mg左旋多巴后，T1 MRI信号强度的变化导致灰质自动分类的变化结果VBM分析显示，左旋多巴可使黑质、被盖腹侧区和双侧丘脑底核的灰质体素数目增加，这些核团是多巴胺能神经系统投射的主要起源和第一中继核团（t = 8.61;校正所有灰质体积P < 0.001）。结论我们的研究结果表明，左旋多巴给药可引起MRI T1信号强度的变化，这是不明显的肉眼，但可以通过测量局部信号强度检测。可能的临床应用进行了讨论。
Aim To test T1 intensity variations induced by levodopa administration in the regional fixation area in the human brain.Method Using non-invasive magnetic resonance imaging (MRI) technique [T1-weighted sequence MPRAGE; TE/TR/TI = 5/25/800 ms; impulsion angle = 15 degrees; field of view = 256 x 230 x 180 mm(3); acquisition matrix = 256 x 192 x 104; reconstruction matrix = 256 x 256 x 128), we tested changes in the T1 MRI signal intensity resulting in changes in the grey matter automatic classification after administration of a single dose of 100 mg of levodopa by a voxel-based morphometry method (VBM) in 12 healthy subjects.Result The VBM analysis demonstrated an increased number of voxels attributed to grey matter after levodopa administration in an anatomical cluster which included substantia nigra, tegmental ventral area and subthalamic nucleus bilaterally, the principal origin and first relay nuclei of projections in brain dopaminergic systems (t = 8.61; corrected for all grey matter volume P < 0.001).Conclusion Our results suggest that levodopa administration could induce an MRI T1 signal intensity variation that is not evident to the naked eye, but is detectable by measuring local signal intensities. Possible clinical applications are discussed.