GENETIC TOXICOLOGY STUDIES WITH 2-NITROBENZOFURANS AND 2-NITRONAPHTHOFURANS
GENETIC TOXICOLOGY STUDIES WITH 2-NITROBENZOFURANS AND 2-NITRONAPHTHOFURANS
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DOI：
10.1016/0165-7992(82)90112-9
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
HOFNUNG, M
中科院分区：
文献类型：
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作者：
WEILLTHEVENET, N;BUISSON, JP;HOFNUNG, M
进一步研究了苯并呋喃和萘并呋喃的遗传毒性。7种新的2-硝基呋喃对菌株TA1537、TA1538、TA98、TA100呈阳性反应，而对菌株TA1535不呈阳性反应。这种反应至少部分依赖于细菌硝基还原酶的活性，并且在大鼠肝脏激活混合物的存在下，这种反应被降低。在诱变试验中检测到的诱变效力与在诱导试验中检测到的噬菌体诱导效力之间存在相关性。从化合物对哺乳动物可能的遗传毒性的角度，简要讨论了这些结果以及对UVR+沙门氏菌菌株和Spermatest的补充试验的相关性。
The genetic toxicity of benzofurans and naphthofurans was further examined. Seven new 2-nitronaphthofurans tested give a positive response on strains TA1537, TA1538, TA98, TA100, but not on strain TA1535. This response depends at least partly on the bacterial nitroreductase activities and is decreased in the presence of activating mixture from rat liver. A correlation is observed between the mutagenic potency assayed in the Mutatest and the phage-inducing potency assayed in the Inductest. The relevance of these results and of complementary tests on uvr+ Salmonella strains and the Spermatest are briefly discussed in perspective of the possible genetic toxicity of the compounds on mammals.