ProTherm: Thermodynamic database for proteins and mutants
ProTherm: Thermodynamic database for proteins and mutants
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DOI：
10.1093/nar/27.1.286
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发表时间：
1999-01-01
影响因子：
14.9
通讯作者：
Sarai, A
中科院分区：
文献类型：
--
作者：
Gromiha, MM;An, J;Sarai, A
蛋白质和突变体热力学数据库(ProTherm)的首次发布包含了超过3300个野生型和突变型蛋白质的热力学参数的数据。每个条目包括展开Gibbs自由能变化、热变、热容变化、转变温度、活性等对理解蛋白质稳定性机制至关重要的数值数据，ProTherm还包括结构信息，如野生型残基的二级结构和溶剂可及性，以及实验方法和其他条件。WWW界面使用户能够根据各种条件搜索数据，并为输出提供不同的排序选项。此外，ProTherm还与NCBI PubMed文献数据库、蛋白质突变数据库、酶编码和蛋白质数据库结构数据库进行了交叉链接。此外，与每个PDB结构相关联的所有突变位点都被自动绘制出来，并可以通过我们实验室开发的3DinSight直接查看，该数据库的网址是http://www.rtc.Riken.go.jp/protherm.html。
The first release of the Thermodynamic Database for Proteins and Mutants (ProTherm) contains more than 3300 data of several thermodynamic parameters for wild type and mutant proteins. Each entry includes numerical data for unfolding Gibbs free energy change, enthalpy change, heat capacity change, transition temperature, activity etc., which are important for understanding the mechanism of protein stability, ProTherm also includes structural information such as secondary structure and solvent accessibility of wild type residues, and experimental methods and other conditions. A WWW interface enables users to search data based on various conditions with different sorting options for outputs. Further, ProTherm is cross-linked with NCBI PUBMED literature database, Protein Mutant Database, Enzyme Code and Protein Data Bank structural database. Moreover, all the mutation sites associated with each PDB structure are automatically mapped and can be directly viewed through 3DinSight developed in our laboratory, The database is available at the URL, http://www.rtc. riken.go.jp/protherm.html.