Enriched environment exposure alters the input-output dynamics of synaptic transmission in area CA1 of freely moving rats
Enriched environment exposure alters the input-output dynamics of synaptic transmission in area CA1 of freely moving rats
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DOI：
10.1016/j.neulet.2005.08.031
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发表时间：
2005-12-31
影响因子：
2.5
通讯作者：
Abraham, WC
中科院分区：
文献类型：
--
作者：
Irvine, GI;Abraham, WC
我们在自由活动的动物中检查了 EE 暴露是否直接改变海马 CA1 区的突触传递。成年雄性 Sprague-Dawley 大鼠在 CA1 中长期植入记录和刺激电极，并单独饲养在标准笼子中。在建立场兴奋性突触后电位 (fEPSP) 的稳定记录后，评估了 19 天的三个环境富集水平的影响。仅在重复过夜的丰富环境暴露后才观察到 fEPSP 的变化，因此在高刺激强度下发生反应增强，但在低刺激强度下反应明显减弱。行为测试证实，EE 暴露足以促进空间工作记忆任务的表现。这些结果表明，隔夜 EE 暴露可以改善 CA1 突触传递的动态，从而可能有助于增强信息处理，从而增强海马体依赖性任务的表现。 (C) 2005 Elsevier Ireland Ltd. 保留所有权利。
We examined in freely moving animals whether EE exposure directly alters synaptic transmission in CA1 of the hippocampus. Adult male Sprague-Dawley rats were chronically implanted with recording and stimulating electrodes in CA1 and housed singly in standard cages. After stable recordings were established for field excitatory postsynaptic potentials (fEPSPs), the effects of three levels of environmental enrichment for 19 days were assessed. A change in fEPSPs was observed only after repeated overnight enriched environment exposure, such that response potentiation occurred at high stimulus intensities but a reduced response was evident at low stimulus intensities. Behavioural tests confirmed that EE exposure was sufficient to facilitate performance on spatial working memory tasks. These results suggest that overnight EE exposure refines the dynamics of CA1 synaptic transmission in a way that may contribute to augmented information processing and thus performance on hippocampus-dependent tasks. (C) 2005 Elsevier Ireland Ltd. All rights reserved.